prikaz prve stranice dokumenta Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
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Scientific paper - Original scientific paper
Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
Nature Communications, 15 (2024), 1; 7754. https://doi.org/10.1038/s41467-024-51931-4
Karner, Dubravka; Kveštak, Daria; Kučan Brlić, Paola; Cokaric Brdovčak, Maja; Lisnić, Berislav; Brizić, Ilija; Juranić Lisnić, Vanda; Golemac, Mijo; Tomac, Jelena; Krmpotić, Astrid; Karkeni, Esma; Libri, Valentina; Mella, Sebastien; Legname, Giuseppe; Altmeppen, Hermann C.; Hasan, Milena; Jonjić, Stipan; Lenac Roviš, Tihana More authors...

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Karner, D., Kveštak, D., Kučan Brlić, P., Cokaric Brdovčak, M., Lisnić, B., Brizić, I. ... Lenac Roviš, T. (2024). Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection. Nature Communications, 15. (1). doi: 10.1038/s41467-024-51931-4

Karner, Dubravka, et al. "Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection." Nature Communications, vol. 15, no. 1, 2024. https://doi.org/10.1038/s41467-024-51931-4

Karner, Dubravka, Daria Kveštak, Paola Kučan Brlić, Maja Cokaric Brdovčak, Berislav Lisnić, Ilija Brizić, Vanda Juranić Lisnić, et al. "Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection." Nature Communications 15, no. 1 (2024). https://doi.org/10.1038/s41467-024-51931-4

Karner, D., et al. (2024) 'Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection', Nature Communications, 15(1). doi: 10.1038/s41467-024-51931-4

Karner D, Kveštak D, Kučan Brlić P, Cokaric Brdovčak M, Lisnić B, Brizić I, and sur.. Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection. Nature Communications [Internet]. 2024 September 05 [cited 2024 October 05];15(1). doi: 10.1038/s41467-024-51931-4

D. Karner, et al., "Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection", Nature Communications, vol. 15, no. 1, September 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:510596. [Accessed: 05 October 2024]

Metadata
Title (english)Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
AuthorDubravka Karner
AuthorDaria Kveštak
AuthorPaola Kučan Brlić
AuthorMaja Cokaric Brdovčak
AuthorBerislav Lisnić
AuthorIlija Brizić
AuthorVanda Juranić Lisnić
AuthorMijo Golemac
AuthorJelena Tomac
AuthorAstrid Krmpotić
AuthorEsma Karkeni
AuthorValentina Libri
AuthorSebastien Mella
AuthorGiuseppe Legname
AuthorHermann C. Altmeppen
AuthorMilena Hasan
AuthorStipan Jonjić
AuthorTihana Lenac Roviš
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegalovirus (CMV) infection poses risks to newborns, necessitating effective therapies. Given that the damage includes both viral infection of brain cells and immune system-related damage, here we investigate the involvement of cellular prion protein (PrP), which plays vital roles in neuro protection and immune regulation. Using a murine model, we show the role of PrP in tempering neonatal T cell immunity during CMV infection. PrP-null mice exhibit enhanced viral control through elevated virus-specific CD8 T cell responses, leading to reduced viral titers and pathology. We further unravel the molecular mechanisms by showing CMV-induced upregulation followed by release of PrP via the metalloproteinase ADAM10, impairing CD8 T cell response specifically in neonates. Additionally, we confirm PrP down regulation in human CMV (HCMV)-infected fibroblasts, underscoring the broader relevance of our observations beyond the murine model. Further more, our study highlights how PrP, under the stress of viral pathogenesis, reveals its impact on neonatal immune modulation
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Communications
Numberingvol. 15, no. 1, 7754
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-024-51931-4
URN:NBNurn:nbn:hr:184:510596
Publication2024-09-05
Document URLhttps://www.nature.com/articles/s41467-024-51931-4
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-09-16 12:00:15