prikaz prve stranice dokumenta Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
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Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
Nature Communications, 15 (2024), 1; 7754. https://doi.org/10.1038/s41467-024-51931-4
Karner, Dubravka; Kveštak, Daria; Kučan Brlić, Paola; Cokaric Brdovčak, Maja; Lisnić, Berislav; Brizić, Ilija; Juranić Lisnić, Vanda; Golemac, Mijo; Tomac, Jelena; Krmpotić, Astrid; Karkeni, Esma; Libri, Valentina; Mella, Sebastien; Legname, Giuseppe; Altmeppen, Hermann C.; Hasan, Milena; Jonjić, Stipan; Lenac Roviš, Tihana Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Karner, D., Kveštak, D., Kučan Brlić, P., Cokaric Brdovčak, M., Lisnić, B., Brizić, I. ... Lenac Roviš, T. (2024). Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection. Nature Communications, 15. (1). doi: 10.1038/s41467-024-51931-4

Karner, Dubravka, et al. "Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection." Nature Communications, vol. 15, br. 1, 2024. https://doi.org/10.1038/s41467-024-51931-4

Karner, Dubravka, Daria Kveštak, Paola Kučan Brlić, Maja Cokaric Brdovčak, Berislav Lisnić, Ilija Brizić, Vanda Juranić Lisnić, et al. "Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection." Nature Communications 15, br. 1 (2024). https://doi.org/10.1038/s41467-024-51931-4

Karner, D., et al. (2024) 'Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection', Nature Communications, 15(1). doi: 10.1038/s41467-024-51931-4

Karner D, Kveštak D, Kučan Brlić P, Cokaric Brdovčak M, Lisnić B, Brizić I, i sur.. Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection. Nature Communications [Internet]. 05.09.2024. [pristupljeno 05.10.2024.];15(1). doi: 10.1038/s41467-024-51931-4

D. Karner, et al., "Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection", Nature Communications, vol. 15, br. 1, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:510596. [Citirano: 05.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:510596
Podaci o radu
Naslov (engleski)Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
AutorDubravka Karner
AutorDaria Kveštak
AutorPaola Kučan Brlić
AutorMaja Cokaric Brdovčak
AutorBerislav Lisnić
AutorIlija Brizić
AutorVanda Juranić Lisnić
AutorMijo Golemac
AutorJelena Tomac
AutorAstrid Krmpotić
AutorEsma Karkeni
AutorValentina Libri
AutorSebastien Mella
AutorGiuseppe Legname
AutorHermann C. Altmeppen
AutorMilena Hasan
AutorStipan Jonjić
AutorTihana Lenac Roviš
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegalovirus (CMV) infection poses risks to newborns, necessitating effective therapies. Given that the damage includes both viral infection of brain cells and immune system-related damage, here we investigate the involvement of cellular prion protein (PrP), which plays vital roles in neuro protection and immune regulation. Using a murine model, we show the role of PrP in tempering neonatal T cell immunity during CMV infection. PrP-null mice exhibit enhanced viral control through elevated virus-specific CD8 T cell responses, leading to reduced viral titers and pathology. We further unravel the molecular mechanisms by showing CMV-induced upregulation followed by release of PrP via the metalloproteinase ADAM10, impairing CD8 T cell response specifically in neonates. Additionally, we confirm PrP down regulation in human CMV (HCMV)-infected fibroblasts, underscoring the broader relevance of our observations beyond the murine model. Further more, our study highlights how PrP, under the stress of viral pathogenesis, reveals its impact on neonatal immune modulation
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 15, br. 1, 7754
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-024-51931-4
URN:NBNurn:nbn:hr:184:510596
Datum objave publikacije2024-09-05
URL dokumentahttps://www.nature.com/articles/s41467-024-51931-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-09-16 12:00:15