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Scientific paper - Original scientific paper
The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia
Biomedicines, 12 (2024), 10; 2263. https://doi.org/10.3390/biomedicines12102263
Karačić, Andrija; Renko, Ira; Krznarić, Željko; Klobučar, Sanja; Liberati Pršo, Ana-Marija

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Karačić, A., Renko, I., Krznarić, Ž., Klobučar, S. & Liberati Pršo, A. M. (2024). The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia. Biomedicines, 12. (10). doi: 10.3390/biomedicines12102263

Karačić, Andrija, et al. "The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia." Biomedicines, vol. 12, no. 10, 2024. https://doi.org/10.3390/biomedicines12102263

Karačić, Andrija, Ira Renko, Željko Krznarić, Sanja Klobučar and Ana Marija Liberati Pršo. "The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia." Biomedicines 12, no. 10 (2024). https://doi.org/10.3390/biomedicines12102263

Karačić, A., et al. (2024) 'The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia', Biomedicines, 12(10). doi: 10.3390/biomedicines12102263

Karačić A, Renko I, Krznarić Ž, Klobučar S, Liberati Pršo AM. The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia. Biomedicines [Internet]. 2024 October 04 [cited 2024 November 23];12(10). doi: 10.3390/biomedicines12102263

A. Karačić, I. Renko, Ž. Krznarić, S. Klobučar and A. M. Liberati Pršo, "The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia", Biomedicines, vol. 12, no. 10, October 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:748983. [Accessed: 23 November 2024]

Metadata
Title (english)The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia
AuthorAndrija Karačić
AuthorIra Renko
AuthorŽeljko Krznarić
AuthorSanja Klobučar
AuthorAna-Marija Liberati Pršo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background/Objectives: The phyla Firmicutes and Bacteroidetes are the main constituents of the gut microbiota. An imbalance in the gut microbiota is a sign of dysbiosis, and the Firmicutes-to-Bacteroidetes ratio has been proposed to be a marker of it, especially in the context of obesity. Since Croatia is the country with one of the highest obesity rates in Europe, a pilot observational study was conducted. The aim of the study was to investigate the validity of this potential biomarker in a methodological study using sample processing, DNA sequence analysis and characterization of recruited participants, including various health factors. Methods: A study involving Croatian population was conducted. Participants age, body weight, gender, health history and lifestyle factors were recorded. Gut microbiota composition was analyzed using 16S rRNA sequencing. The F/B ratio was calculated and evaluated in the context of health factors. Statistical analysis was performed to detect the possible association of F/B ratio and excess body weight (kg) and possible impact of certain lifestyle factors. Results: No association between the F/B ratio and excess body weight (kg) was found. Excess body weight was significantly associated with higher age, male gender, and history of appendectomy. No significant health predictors of the F/B ratio were found, but weight gain was positively associated with a higher average F/B ratio. Conclusions: Although this study could not confirm the predictive value of the F/B ratio or any other phyla-related biomarker for excess body weight in the study population, it demonstrated interesting insights into the obesity-associated gut microbiota.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 12, no. 10, 2263
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12102263
URN:NBNurn:nbn:hr:184:748983
Publication2024-10-04
Document URLhttps://www.mdpi.com/2227-9059/12/10/2263
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-10-07 10:02:15