prikaz prve stranice dokumenta Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study
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Scientific paper - Original scientific paper
Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study
Croatian Medical Journal, 65 (2024), 4; 328-338. https://doi.org/10.3325/cmj.2024.65.328
Brgić Mandić, Klara; Mrak, Goran; Barić, Hrvoje; Marasanov, Sergej; Šimić, Goran; Španić Popovački, Ena; Klarica, Marijan

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Brgić Mandić, K., Mrak, G., Barić, H., Marasanov, S., Šimić, G., Španić Popovački, E. & Klarica, M. (2024). Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study. Croatian Medical Journal, 65. (4), 328-338. doi: 10.3325/cmj.2024.65.328

Brgić Mandić, Klara, et al. "Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study." Croatian Medical Journal, vol. 65, no. 4, 2024, pp. 328-338. https://doi.org/10.3325/cmj.2024.65.328

Brgić Mandić, Klara, Goran Mrak, Hrvoje Barić, Sergej Marasanov, Goran Šimić, Ena Španić Popovački and Marijan Klarica. "Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study." Croatian Medical Journal 65, no. 4 (2024): 328-338. https://doi.org/10.3325/cmj.2024.65.328

Brgić Mandić, K., et al. (2024) 'Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study', Croatian Medical Journal, 65(4), pp. 328-338. doi: 10.3325/cmj.2024.65.328

Brgić Mandić K, Mrak G, Barić H, Marasanov S, Šimić G, Španić Popovački E, and sur.. Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study. Croatian Medical Journal [Internet]. 2024 August [cited 2024 October 07];65(4):328-338. doi: 10.3325/cmj.2024.65.328

K. Brgić Mandić, et al., "Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study", Croatian Medical Journal, vol. 65, no. 4, pp. 328-338, August 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:972063. [Accessed: 07 October 2024]

Metadata
Title (english)Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study
AuthorKlara Brgić Mandić
AuthorGoran Mrak
AuthorHrvoje Barić
AuthorSergej Marasanov
AuthorGoran Šimić
AuthorEna Španić Popovački
AuthorMarijan Klarica
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Aim: To examine whether changes in biomarker concentrations in patients with idiopathic normal-pressure hydrocephalus (iNPH) during 72 h of external lumbar drainage (ELD) can differentiate between responders and non-responders. Methods: Twenty patients with clinical and neuroradiological signs of iNPH underwent ELD over a period of 72 h. During this period, changes in cerebrospinal fluid (CSF) concentrations of biomarkers (amyloid-β, total and phosphorylated tau proteins) and intracranial pressure were monitored, and the volume of drained CSF was measured. Changes in the concentrations of selected biomarkers at three time points (0, 36, and 72 h) during ELD were tested for association with changes in clinical condition. Results: Ten patients showed significant clinical improvement after ELD, quantified as a difference of two or more points on the Mini-Mental State Examination and/or Japanese iNPH grading scale. The concentration of all tested biomarkers increased during the first 36 h. Respondents had higher Aβ 1-42 at all time points, with a significant difference seen after 72 h. They also had a significantly higher Aβ1-42/Aβ1-40 ratio at all time points. Conclusion: A gradual increase in Aβ 1-42 concentration during three-day ELD represents a possible positive prognostic factor for the placement of permanent CSF drainage in patients with iNPH.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 65, no. 4, pp. 328-338
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2024.65.328
URN:NBNurn:nbn:hr:105:972063
Publication2024-08
Document URLhttp://www.cmj.hr/2024/65/4/39219196.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-09-19 08:21:22