prikaz prve stranice dokumenta Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study
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Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study
Croatian Medical Journal, 65 (2024), 4; 328-338. https://doi.org/10.3325/cmj.2024.65.328
Brgić Mandić, Klara; Mrak, Goran; Barić, Hrvoje; Marasanov, Sergej; Šimić, Goran; Španić Popovački, Ena; Klarica, Marijan

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Brgić Mandić, K., Mrak, G., Barić, H., Marasanov, S., Šimić, G., Španić Popovački, E. i Klarica, M. (2024). Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study. Croatian Medical Journal, 65. (4), 328-338. doi: 10.3325/cmj.2024.65.328

Brgić Mandić, Klara, et al. "Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study." Croatian Medical Journal, vol. 65, br. 4, 2024, str. 328-338. https://doi.org/10.3325/cmj.2024.65.328

Brgić Mandić, Klara, Goran Mrak, Hrvoje Barić, Sergej Marasanov, Goran Šimić, Ena Španić Popovački i Marijan Klarica. "Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study." Croatian Medical Journal 65, br. 4 (2024): 328-338. https://doi.org/10.3325/cmj.2024.65.328

Brgić Mandić, K., et al. (2024) 'Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study', Croatian Medical Journal, 65(4), str. 328-338. doi: 10.3325/cmj.2024.65.328

Brgić Mandić K, Mrak G, Barić H, Marasanov S, Šimić G, Španić Popovački E, i sur.. Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study. Croatian Medical Journal [Internet]. 08.2024. [pristupljeno 06.10.2024.];65(4):328-338. doi: 10.3325/cmj.2024.65.328

K. Brgić Mandić, et al., "Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study", Croatian Medical Journal, vol. 65, br. 4, str. 328-338, Kolovoz 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:972063. [Citirano: 06.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:972063
Podaci o radu
Naslov (engleski)Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study
AutorKlara Brgić Mandić
AutorGoran Mrak
AutorHrvoje Barić
AutorSergej Marasanov
AutorGoran Šimić
AutorEna Španić Popovački
AutorMarijan Klarica
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Aim: To examine whether changes in biomarker concentrations in patients with idiopathic normal-pressure hydrocephalus (iNPH) during 72 h of external lumbar drainage (ELD) can differentiate between responders and non-responders. Methods: Twenty patients with clinical and neuroradiological signs of iNPH underwent ELD over a period of 72 h. During this period, changes in cerebrospinal fluid (CSF) concentrations of biomarkers (amyloid-β, total and phosphorylated tau proteins) and intracranial pressure were monitored, and the volume of drained CSF was measured. Changes in the concentrations of selected biomarkers at three time points (0, 36, and 72 h) during ELD were tested for association with changes in clinical condition. Results: Ten patients showed significant clinical improvement after ELD, quantified as a difference of two or more points on the Mini-Mental State Examination and/or Japanese iNPH grading scale. The concentration of all tested biomarkers increased during the first 36 h. Respondents had higher Aβ 1-42 at all time points, with a significant difference seen after 72 h. They also had a significantly higher Aβ1-42/Aβ1-40 ratio at all time points. Conclusion: A gradual increase in Aβ 1-42 concentration during three-day ELD represents a possible positive prognostic factor for the placement of permanent CSF drainage in patients with iNPH.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 65, br. 4, str. 328-338
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2024.65.328
URN:NBNurn:nbn:hr:105:972063
Datum objave publikacije2024-08
URL dokumentahttp://www.cmj.hr/2024/65/4/39219196.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-09-19 08:21:22