prikaz prve stranice dokumenta Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers
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Scientific paper - Review paper
Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers
International Journal of Molecular Sciences, 25 (2024), 2; 1335. https://doi.org/10.3390/ijms25021335
Biricioiu, Maria Roxana; Sarbu, Mirela; Ica, Raluca; Vukelić, Željka; Kalanj-Bognar, Svjetlana; Zamfir, Alina D.

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Biricioiu, M. R., Sarbu, M., Ica, R., Vukelić, Ž., Kalanj Bognar, S. & Zamfir, A. D. (2024). Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers. International Journal of Molecular Sciences, 25. (2). doi: 10.3390/ijms25021335

Biricioiu, Maria Roxana, et al. "Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers." International Journal of Molecular Sciences, vol. 25, no. 2, 2024. https://doi.org/10.3390/ijms25021335

Biricioiu, Maria Roxana, Mirela Sarbu, Raluca Ica, Željka Vukelić, Svjetlana Kalanj Bognar and Alina D. Zamfir. "Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers." International Journal of Molecular Sciences 25, no. 2 (2024). https://doi.org/10.3390/ijms25021335

Biricioiu, M. R., et al. (2024) 'Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers', International Journal of Molecular Sciences, 25(2). doi: 10.3390/ijms25021335

Biricioiu MR, Sarbu M, Ica R, Vukelić Ž, Kalanj Bognar S, Zamfir AD. Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers. International Journal of Molecular Sciences [Internet]. 2024 January 22 [cited 2024 December 27];25(2). doi: 10.3390/ijms25021335

M. R. Biricioiu, M. Sarbu, R. Ica, Ž. Vukelić, S. Kalanj Bognar and A. D. Zamfir, "Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers", International Journal of Molecular Sciences, vol. 25, no. 2, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:416331. [Accessed: 27 December 2024]

Metadata
Title (english)Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers
AuthorMaria Roxana Biricioiu
AuthorMirela Sarbu
AuthorRaluca Ica
AuthorŽeljka Vukelić
AuthorSvjetlana Kalanj-Bognar
AuthorAlina D. Zamfir
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Chemistry, Biochemistry and Clinical Chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Gangliosides are highly abundant in the human brain where they are involved in major biological events. In brain cancers, alterations of ganglioside pattern occur, some of which being correlated with neoplastic transformation, while others with tumor proliferation. Of all techniques, mass spectrometry (MS) has proven to be one of the most effective in gangliosidomics, due to its ability to characterize heterogeneous mixtures and discover species with biomarker value. This review highlights the most significant achievements of MS in the analysis of gangliosides in human brain cancers. The first part presents the latest state of MS development in the discovery of ganglioside markers in primary brain tumors, with a particular emphasis on the ion mobility separation (IMS) MS and its contribution to the elucidation of the gangliosidome associated with aggressive tumors. The second part is focused on MS of gangliosides in brain metastases, highlighting the ability of matrix-assisted laser desorption/ionization (MALDI)-MS, microfluidics-MS and tandem MS to decipher and structurally characterize species involved in the metastatic process. In the end, several conclusions and perspectives are presented, among which the need for development of reliable software and a user-friendly structural database as a search platform in brain tumor diagnostics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 2, 1335
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25021335
URN:NBNurn:nbn:hr:105:416331
Publication2024-01-22
Document URLhttps://www.mdpi.com/1422-0067/25/2/1335
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-12-03 08:34:57