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Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers
International Journal of Molecular Sciences, 25 (2024), 2; 1335. https://doi.org/10.3390/ijms25021335
Biricioiu, Maria Roxana; Sarbu, Mirela; Ica, Raluca; Vukelić, Željka; Kalanj-Bognar, Svjetlana; Zamfir, Alina D.

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Biricioiu, M. R., Sarbu, M., Ica, R., Vukelić, Ž., Kalanj Bognar, S. i Zamfir, A. D. (2024). Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers. International Journal of Molecular Sciences, 25. (2). doi: 10.3390/ijms25021335

Biricioiu, Maria Roxana, et al. "Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers." International Journal of Molecular Sciences, vol. 25, br. 2, 2024. https://doi.org/10.3390/ijms25021335

Biricioiu, Maria Roxana, Mirela Sarbu, Raluca Ica, Željka Vukelić, Svjetlana Kalanj Bognar i Alina D. Zamfir. "Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers." International Journal of Molecular Sciences 25, br. 2 (2024). https://doi.org/10.3390/ijms25021335

Biricioiu, M. R., et al. (2024) 'Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers', International Journal of Molecular Sciences, 25(2). doi: 10.3390/ijms25021335

Biricioiu MR, Sarbu M, Ica R, Vukelić Ž, Kalanj Bognar S, Zamfir AD. Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers. International Journal of Molecular Sciences [Internet]. 22.01.2024. [pristupljeno 27.12.2024.];25(2). doi: 10.3390/ijms25021335

M. R. Biricioiu, M. Sarbu, R. Ica, Ž. Vukelić, S. Kalanj Bognar i A. D. Zamfir, "Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers", International Journal of Molecular Sciences, vol. 25, br. 2, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:416331. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:416331
Podaci o radu
Naslov (engleski)Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers
AutorMaria Roxana Biricioiu
AutorMirela Sarbu
AutorRaluca Ica
AutorŽeljka Vukelić
AutorSvjetlana Kalanj-Bognar
AutorAlina D. Zamfir
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU KEMIJU, BIOKEMIJU I KLINIČKU KEMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Gangliosides are highly abundant in the human brain where they are involved in major biological events. In brain cancers, alterations of ganglioside pattern occur, some of which being correlated with neoplastic transformation, while others with tumor proliferation. Of all techniques, mass spectrometry (MS) has proven to be one of the most effective in gangliosidomics, due to its ability to characterize heterogeneous mixtures and discover species with biomarker value. This review highlights the most significant achievements of MS in the analysis of gangliosides in human brain cancers. The first part presents the latest state of MS development in the discovery of ganglioside markers in primary brain tumors, with a particular emphasis on the ion mobility separation (IMS) MS and its contribution to the elucidation of the gangliosidome associated with aggressive tumors. The second part is focused on MS of gangliosides in brain metastases, highlighting the ability of matrix-assisted laser desorption/ionization (MALDI)-MS, microfluidics-MS and tandem MS to decipher and structurally characterize species involved in the metastatic process. In the end, several conclusions and perspectives are presented, among which the need for development of reliable software and a user-friendly structural database as a search platform in brain tumor diagnostics.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 2, 1335
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25021335
URN:NBNurn:nbn:hr:105:416331
Datum objave publikacije2024-01-22
URL dokumentahttps://www.mdpi.com/1422-0067/25/2/1335
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-03 08:34:57