prikaz prve stranice dokumenta Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms
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Scientific paper - Original scientific paper
Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms
Journal of Alzheimer's Disease, 73 (2020), 1; 135-145. https://doi.org/10.3233/JAD-190991
Babić Leko, Mirjana; Nikolac Perković, Matea; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Nikolac Perković, M., Klepac, N., Švob Štrac, D., Borovečki, F., Pivac, N. ... Šimić, G. (2020). Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms. Journal of Alzheimer's Disease, 73. (1), 135-145. doi: 10.3233/JAD-190991

Babić Leko, Mirjana, et al. "Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms." Journal of Alzheimer's Disease, vol. 73, no. 1, 2020, pp. 135-145. https://doi.org/10.3233/JAD-190991

Babić Leko, Mirjana, Matea Nikolac Perković, Nataša Klepac, Dubravka Švob Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof and Goran Šimić. "Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms." Journal of Alzheimer's Disease 73, no. 1 (2020): 135-145. https://doi.org/10.3233/JAD-190991

Babić Leko, M., et al. (2020) 'Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms', Journal of Alzheimer's Disease, 73(1), pp. 135-145. doi: 10.3233/JAD-190991

Babić Leko M, Nikolac Perković M, Klepac N, Švob Štrac D, Borovečki F, Pivac N, and sur.. Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms. Journal of Alzheimer's Disease [Internet]. 2020 January 07 [cited 2024 December 30];73(1):135-145. doi: 10.3233/JAD-190991

M. Babić Leko, et al., "Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms", Journal of Alzheimer's Disease, vol. 73, no. 1, pp. 135-145, January 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:926875. [Accessed: 30 December 2024]

Metadata
Title (english)Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms
AuthorMirjana Babić Leko
AuthorMatea Nikolac Perković
AuthorNataša Klepac
AuthorDubravka Švob Štrac
AuthorFran Borovečki
AuthorNela Pivac
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
The noradrenergic and dopaminergic systems are affected in Alzheimer’s disease (AD). Polymorphisms in genes encoding enzymes and proteins that are components of these systems can affect products of transcription and translation and lead to altered enzymatic activity and alterations in overall dopamine and noradrenaline levels. Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine - hydroxylase (DBH) is involved in synthesis of noradrenaline. COMT Val158Met (rs4680), DBH rs1611115 (also called –1021C/T or –970C/T), and MAOB rs1799836 (also called A644G) polymorphisms have been previously associated with AD. We assessed whether these polymorphisms are associated with cerebrospinal fluid (CSF) AD biomarkers including total tau (t-tau), phosphorylated tau proteins (p-tau181, p-tau199, and p-tau231), amyloid-42 (A42), and visinin-like protein 1 (VILIP-1) to test possible relationships of specific genotypes and pathological levels of CSF AD biomarkers. The study included 233 subjects: 115 AD, 53 mild cognitive impairment, 54 subjects with other primary causes of dementia, and 11 healthy controls. Significant decrease in A42 levels was found in patients with GG compared to AG COMT Val158Met genotype, while t-tau and p-tau181 levels were increased in patients with AA compared to AG COMT Val158Met genotype. A42 levels were also decreased in carriers of A allele in MAO-B rs1799836 polymorphism, while p-tau181 levels were increased in carriers of T allele in DBH rs1611115 polymorphism. These results indicate that COMT Val158Met, DBH rs1611115, and MAOB rs1799836 polymorphisms deserve further investigation as genetic markers of AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Alzheimer's Disease
Numberingvol. 73, no. 1, pp. 135-145
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-190991
URN:NBNurn:nbn:hr:105:926875
Publication2020-01-07
Document URLhttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-190991
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2020-10-26 09:53:49