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Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms
Journal of Alzheimer's Disease, 73 (2020), 1; 135-145. https://doi.org/10.3233/JAD-190991
Babić Leko, Mirjana; Nikolac Perković, Matea; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Babić Leko, M., Nikolac Perković, M., Klepac, N., Švob Štrac, D., Borovečki, F., Pivac, N. ... Šimić, G. (2020). Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms. Journal of Alzheimer's Disease, 73. (1), 135-145. doi: 10.3233/JAD-190991

Babić Leko, Mirjana, et al. "Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms." Journal of Alzheimer's Disease, vol. 73, br. 1, 2020, str. 135-145. https://doi.org/10.3233/JAD-190991

Babić Leko, Mirjana, Matea Nikolac Perković, Nataša Klepac, Dubravka Švob Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof i Goran Šimić. "Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms." Journal of Alzheimer's Disease 73, br. 1 (2020): 135-145. https://doi.org/10.3233/JAD-190991

Babić Leko, M., et al. (2020) 'Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms', Journal of Alzheimer's Disease, 73(1), str. 135-145. doi: 10.3233/JAD-190991

Babić Leko M, Nikolac Perković M, Klepac N, Švob Štrac D, Borovečki F, Pivac N, i sur.. Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms. Journal of Alzheimer's Disease [Internet]. 07.01.2020. [pristupljeno 05.11.2024.];73(1):135-145. doi: 10.3233/JAD-190991

M. Babić Leko, et al., "Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms", Journal of Alzheimer's Disease, vol. 73, br. 1, str. 135-145, Siječanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:926875. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:926875
Podaci o radu
Naslov (engleski)Relationships of Cerebrospinal Fluid Alzheimer’s Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms
AutorMirjana Babić Leko
AutorMatea Nikolac Perković
AutorNataša Klepac
AutorDubravka Švob Štrac
AutorFran Borovečki
AutorNela Pivac
AutorPatrick R. Hof
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
The noradrenergic and dopaminergic systems are affected in Alzheimer’s disease (AD). Polymorphisms in genes encoding enzymes and proteins that are components of these systems can affect products of transcription and translation and lead to altered enzymatic activity and alterations in overall dopamine and noradrenaline levels. Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine - hydroxylase (DBH) is involved in synthesis of noradrenaline. COMT Val158Met (rs4680), DBH rs1611115 (also called –1021C/T or –970C/T), and MAOB rs1799836 (also called A644G) polymorphisms have been previously associated with AD. We assessed whether these polymorphisms are associated with cerebrospinal fluid (CSF) AD biomarkers including total tau (t-tau), phosphorylated tau proteins (p-tau181, p-tau199, and p-tau231), amyloid-42 (A42), and visinin-like protein 1 (VILIP-1) to test possible relationships of specific genotypes and pathological levels of CSF AD biomarkers. The study included 233 subjects: 115 AD, 53 mild cognitive impairment, 54 subjects with other primary causes of dementia, and 11 healthy controls. Significant decrease in A42 levels was found in patients with GG compared to AG COMT Val158Met genotype, while t-tau and p-tau181 levels were increased in patients with AA compared to AG COMT Val158Met genotype. A42 levels were also decreased in carriers of A allele in MAO-B rs1799836 polymorphism, while p-tau181 levels were increased in carriers of T allele in DBH rs1611115 polymorphism. These results indicate that COMT Val158Met, DBH rs1611115, and MAOB rs1799836 polymorphisms deserve further investigation as genetic markers of AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Alzheimer's Disease
Brojčani podacivol. 73, br. 1, str. 135-145
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-190991
URN:NBNurn:nbn:hr:105:926875
Datum objave publikacije2020-01-07
URL dokumentahttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-190991
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2020-10-26 09:53:49