prikaz prve stranice dokumenta The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study
  Download
PDF 309.65 KB
Scientific paper - Original scientific paper
The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study
Croatian Medical Journal, 61 (2020), 1; 40-48. https://doi.org/10.3325/cmj.2020.61.40
Pavlov, Marin; Babić, Zdravko; Đuzel, Ana; Crljenko, Krešimir; Nedić, Mislav; Delić Brkljačić, Diana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Pavlov, M., Babić, Z., Đuzel, A., Crljenko, K., Nedić, M. & Delić Brkljačić, D. (2020). The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study. Croatian Medical Journal, 61. (1), 40-48. doi: 10.3325/cmj.2020.61.40

Pavlov, Marin, et al. "The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study." Croatian Medical Journal, vol. 61, no. 1, 2020, pp. 40-48. https://doi.org/10.3325/cmj.2020.61.40

Pavlov, Marin, Zdravko Babić, Ana Đuzel, Krešimir Crljenko, Mislav Nedić and Diana Delić Brkljačić. "The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study." Croatian Medical Journal 61, no. 1 (2020): 40-48. https://doi.org/10.3325/cmj.2020.61.40

Pavlov, M., et al. (2020) 'The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study', Croatian Medical Journal, 61(1), pp. 40-48. doi: 10.3325/cmj.2020.61.40

Pavlov M, Babić Z, Đuzel A, Crljenko K, Nedić M, Delić Brkljačić D. The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study. Croatian Medical Journal [Internet]. 2020 February 29 [cited 2024 November 23];61(1):40-48. doi: 10.3325/cmj.2020.61.40

M. Pavlov, Z. Babić, A. Đuzel, K. Crljenko, M. Nedić and D. Delić Brkljačić, "The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study", Croatian Medical Journal, vol. 61, no. 1, pp. 40-48, February 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:017640. [Accessed: 23 November 2024]

Metadata
Title (english)The influence of therapeutic hypothermia on the outcomes of cardiac arrest survivors: a retrospective cohort study
AuthorMarin Pavlov
AuthorZdravko Babić
AuthorAna Đuzel
AuthorKrešimir Crljenko
AuthorMislav Nedić
AuthorDiana Delić Brkljačić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: To determine whether therapeutic hypothermia (TH) improves survival and neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors. ----- Methods: This retrospective cohort study enrolled patients treated for OHCA with a return of spontaneous circulation admitted to the Cardiac Intensive Care Unit from October 2000 until March 2019. Data were collected from medical archives. Propensity score matching was used. The primary endpoint was death during hospital stay and secondary endpoint was cerebral performance category (CPC) score at discharge. ----- Results: Out of 152 patients included in the study, 58 (38.7%) underwent TH treatment. After matching (which left 70 patients in the analysis), death during hospital stay occurred less often in TH group (28.6% vs 57.1%, P=0.029), while the difference in CPC score was not significant. Cox proportional hazards model showed the predictors of death during hospital stay to be TH (hazard ratio [HR] 0.29, 95% confidence interval [CI] 0.13-0.68, P=0.004), initial Glasgow Coma Scale score of 3 (HR 7.55, 95% CI 1.44-39.63, P=0.017), and heart failure (HR 2.35, 95% CI 1.02-5.34, P=0.045). TH was not an independent predictor of CPC score. Mann-Whitney U test and linear regression model showed that TH was associated with higher gain in GCS. ----- Conclusion: TH was associated with better survival and certain variables suggesting improved neurological outcomes, suggesting that TH is a vital treatment option for comatose OHCA survivors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 61, no. 1, pp. 40-48
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.40
URN:NBNurn:nbn:hr:105:017640
Publication2020-02-29
Document URLhttp://www.cmj.hr/2020/61/1/32118377.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-10-29 11:47:16