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Scientific paper - Review paper
Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review
Vascular and Endovascular Surgery, 53 (2019), 7; 602-605. https://doi.org/10.1177/1538574419857965
Toljan, Karlo; Jovanović, Ivan; Starčević, Katarina; Ljevak, Josip; Blažević, Nikola; Radoš, Marko; Poljaković, Zdravka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Toljan, K., Jovanović, I., Starčević, K., Ljevak, J., Blažević, N., Radoš, M. & Poljaković, Z. (2019). Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review. Vascular and Endovascular Surgery, 53. (7), 602-605. doi: 10.1177/1538574419857965

Toljan, Karlo, et al. "Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review." Vascular and Endovascular Surgery, vol. 53, no. 7, 2019, pp. 602-605. https://doi.org/10.1177/1538574419857965

Toljan, Karlo, Ivan Jovanović, Katarina Starčević, Josip Ljevak, Nikola Blažević, Marko Radoš and Zdravka Poljaković. "Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review." Vascular and Endovascular Surgery 53, no. 7 (2019): 602-605. https://doi.org/10.1177/1538574419857965

Toljan, K., et al. (2019) 'Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review', Vascular and Endovascular Surgery, 53(7), pp. 602-605. doi: 10.1177/1538574419857965

Toljan K, Jovanović I, Starčević K, Ljevak J, Blažević N, Radoš M, and sur.. Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review. Vascular and Endovascular Surgery [Internet]. 2019 October [cited 2024 November 26];53(7):602-605. doi: 10.1177/1538574419857965

K. Toljan, et al., "Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review", Vascular and Endovascular Surgery, vol. 53, no. 7, pp. 602-605, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:489880. [Accessed: 26 November 2024]

Metadata
Title (english)Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review
AuthorKarlo Toljan
AuthorIvan Jovanović
AuthorKatarina Starčević
AuthorJosip Ljevak
AuthorNikola Blažević
AuthorMarko Radoš
AuthorZdravka Poljaković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Radiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiology
Abstract (english)
Introduction: Carotid angioplasty and stenting (CAS) represents an effective procedure for treating carotid artery disease. The acute in-stent thrombosis is an extremely rare complication of CAS especially when it occurs postprocedurally during the first 24 hours. Improper antiplatelet therapy or poor response to antiplatelet medications is known to be associated with a higher risk of in-stent thrombosis during early postprocedural period following a successful intervention. ----- Material and methods: A patient who experienced acute carotid in-stent thrombosis in early postprocedural period is described. He had been taking dual antiplatelet therapy for 2 weeks before undergoing a successful CAS. Moreover, pharmacogenetics studies showed the patient to be a clopidogrel ultrarapid metabolizer, which theoretically confers hyperresponsivity to medication. Alongside the report itself, a brief literature review of relevant sources pertinent to the case has been conducted. ----- Results: According to the available literature, this is the first case report describing an ultrarapid clopidogrel metabolizer who underwent an uneventful CAS but experienced acute carotid in-stent thrombosis in early postprocedural period. A rescue procedure included an endovascular intervention consisting of thrombectomy and local alteplase application, followed by postprocedural administration of intravenous eptifibatide. At discharge, patient's dual antiplatelet therapy included ticagrelor instead of clopidogrel. ----- Conclusion: Acute carotid in-stent thrombosis is a highly unexpected complication of CAS and can occur despite ultrarapid clopidogrel metabolism trait.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleVascular and Endovascular Surgery
Numberingvol. 53, no. 7, pp. 602-605
p-ISSN1538-5744
e-ISSN1938-9116
DOIhttps://doi.org/10.1177/1538574419857965
URN:NBNurn:nbn:hr:105:489880
Publication2019-10
Document URLhttp://journals.sagepub.com/doi/10.1177/1538574419857965
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-02-08 12:28:49