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Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review
Vascular and Endovascular Surgery, 53 (2019), 7; 602-605. https://doi.org/10.1177/1538574419857965
Toljan, Karlo; Jovanović, Ivan; Starčević, Katarina; Ljevak, Josip; Blažević, Nikola; Radoš, Marko; Poljaković, Zdravka

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Toljan, K., Jovanović, I., Starčević, K., Ljevak, J., Blažević, N., Radoš, M. i Poljaković, Z. (2019). Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review. Vascular and Endovascular Surgery, 53. (7), 602-605. doi: 10.1177/1538574419857965

Toljan, Karlo, et al. "Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review." Vascular and Endovascular Surgery, vol. 53, br. 7, 2019, str. 602-605. https://doi.org/10.1177/1538574419857965

Toljan, Karlo, Ivan Jovanović, Katarina Starčević, Josip Ljevak, Nikola Blažević, Marko Radoš i Zdravka Poljaković. "Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review." Vascular and Endovascular Surgery 53, br. 7 (2019): 602-605. https://doi.org/10.1177/1538574419857965

Toljan, K., et al. (2019) 'Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review', Vascular and Endovascular Surgery, 53(7), str. 602-605. doi: 10.1177/1538574419857965

Toljan K, Jovanović I, Starčević K, Ljevak J, Blažević N, Radoš M, i sur.. Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review. Vascular and Endovascular Surgery [Internet]. 10.2019. [pristupljeno 08.11.2024.];53(7):602-605. doi: 10.1177/1538574419857965

K. Toljan, et al., "Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review", Vascular and Endovascular Surgery, vol. 53, br. 7, str. 602-605, Listopad 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:489880. [Citirano: 08.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:489880
Podaci o radu
Naslov (engleski)Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review
AutorKarlo Toljan
AutorIvan Jovanović
AutorKatarina Starčević
AutorJosip Ljevak
AutorNikola Blažević
AutorMarko Radoš
AutorZdravka Poljaković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA RADIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Radiologija
Sažetak (engleski)
Introduction: Carotid angioplasty and stenting (CAS) represents an effective procedure for treating carotid artery disease. The acute in-stent thrombosis is an extremely rare complication of CAS especially when it occurs postprocedurally during the first 24 hours. Improper antiplatelet therapy or poor response to antiplatelet medications is known to be associated with a higher risk of in-stent thrombosis during early postprocedural period following a successful intervention. ----- Material and methods: A patient who experienced acute carotid in-stent thrombosis in early postprocedural period is described. He had been taking dual antiplatelet therapy for 2 weeks before undergoing a successful CAS. Moreover, pharmacogenetics studies showed the patient to be a clopidogrel ultrarapid metabolizer, which theoretically confers hyperresponsivity to medication. Alongside the report itself, a brief literature review of relevant sources pertinent to the case has been conducted. ----- Results: According to the available literature, this is the first case report describing an ultrarapid clopidogrel metabolizer who underwent an uneventful CAS but experienced acute carotid in-stent thrombosis in early postprocedural period. A rescue procedure included an endovascular intervention consisting of thrombectomy and local alteplase application, followed by postprocedural administration of intravenous eptifibatide. At discharge, patient's dual antiplatelet therapy included ticagrelor instead of clopidogrel. ----- Conclusion: Acute carotid in-stent thrombosis is a highly unexpected complication of CAS and can occur despite ultrarapid clopidogrel metabolism trait.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaVascular and Endovascular Surgery
Brojčani podacivol. 53, br. 7, str. 602-605
p-ISSN1538-5744
e-ISSN1938-9116
DOIhttps://doi.org/10.1177/1538574419857965
URN:NBNurn:nbn:hr:105:489880
Datum objave publikacije2019-10
URL dokumentahttp://journals.sagepub.com/doi/10.1177/1538574419857965
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-02-08 12:28:49