prikaz prve stranice dokumenta Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia
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Scientific paper - Original scientific paper
Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia
Scientific Reports, 9 (2019), 1; 17307. https://doi.org/10.1038/s41598-019-53520-8
Oroz, Maja; Begovac, Josip; Planinić, Ana; Rokić, Filip; Lunar, Maja M.; Zorec, Tomaž Mark; Beluzić, Robert; Korać, Petra; Vugrek, Oliver; Poljak, Mario; Lepej, Snježana Židovec

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Oroz, M., Begovac, J., Planinić, A., Rokić, F., Lunar, M. M., Zorec, T. M. ... Lepej, S. Ž. (2019). Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia. Scientific Reports, 9. (1). doi: 10.1038/s41598-019-53520-8

Oroz, Maja, et al. "Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia." Scientific Reports, vol. 9, no. 1, 2019. https://doi.org/10.1038/s41598-019-53520-8

Oroz, Maja, Josip Begovac, Ana Planinić, Filip Rokić, Maja M. Lunar, Tomaž Mark Zorec, Robert Beluzić, et al. "Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia." Scientific Reports 9, no. 1 (2019). https://doi.org/10.1038/s41598-019-53520-8

Oroz, M., et al. (2019) 'Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia', Scientific Reports, 9(1). doi: 10.1038/s41598-019-53520-8

Oroz M, Begovac J, Planinić A, Rokić F, Lunar MM, Zorec TM, and sur.. Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia. Scientific Reports [Internet]. 2019 November 21 [cited 2024 November 09];9(1). doi: 10.1038/s41598-019-53520-8

M. Oroz, et al., "Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia", Scientific Reports, vol. 9, no. 1, November 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:445560. [Accessed: 09 November 2024]

Metadata
Title (english)Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia
AuthorMaja Oroz
AuthorJosip Begovac
AuthorAna Planinić
AuthorFilip Rokić
AuthorMaja M. Lunar
AuthorTomaž Mark Zorec
AuthorRobert Beluzić
AuthorPetra Korać
AuthorOliver Vugrek
AuthorMario Poljak
AuthorSnježana Židovec Lepej
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Abstract Molecular epidemiology of HIV-1 infection in treatment-naive HIV-1 infected persons from Croatia was investigated. We included 403 persons, representing 92.4% of all HIV-positive individuals entering clinical care in Croatia in 2014–2017. Overall prevalence of transmitted drug resistance (TDR) was estimated at 16.4%. Resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside RTI (NNRTIs) and protease inhibitors (PIs) was found in 11.4%, 6.7% and 2.5% of persons, respectively. Triple-class resistance was determined in 2.2% of individuals. In addition, a single case (1.0%) of resistance to integrase strand-transfer inhibitors (InSTIs) was found. Deep sequencing was performed on 48 randomly selected samples and detected additional TDR mutations in 6 cases. Phylogenetic inference showed that 347/403 sequences (86.1%) were part of transmission clusters and identified forward transmission of resistance in Croatia, even that of triple-class resistance. The largest TDR cluster of 53 persons with T215S was estimated to originate in the year 1992. Our data show a continuing need for pre-treatment HIV resistance testing in Croatia. Even though a low prevalence of resistance to InSTI was observed, surveillance of TDR to InSTI should be continued.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 9, no. 1, 17307
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-019-53520-8
URN:NBNurn:nbn:hr:105:445560
Publication2019-11-21
Document URLhttp://www.nature.com/articles/s41598-019-53520-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-02-15 12:04:38