prikaz prve stranice dokumenta Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia
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Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia
Scientific Reports, 9 (2019), 1; 17307. https://doi.org/10.1038/s41598-019-53520-8
Oroz, Maja; Begovac, Josip; Planinić, Ana; Rokić, Filip; Lunar, Maja M.; Zorec, Tomaž Mark; Beluzić, Robert; Korać, Petra; Vugrek, Oliver; Poljak, Mario; Lepej, Snježana Židovec

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Oroz, M., Begovac, J., Planinić, A., Rokić, F., Lunar, M. M., Zorec, T. M. ... Lepej, S. Ž. (2019). Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia. Scientific Reports, 9. (1). doi: 10.1038/s41598-019-53520-8

Oroz, Maja, et al. "Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia." Scientific Reports, vol. 9, br. 1, 2019. https://doi.org/10.1038/s41598-019-53520-8

Oroz, Maja, Josip Begovac, Ana Planinić, Filip Rokić, Maja M. Lunar, Tomaž Mark Zorec, Robert Beluzić, et al. "Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia." Scientific Reports 9, br. 1 (2019). https://doi.org/10.1038/s41598-019-53520-8

Oroz, M., et al. (2019) 'Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia', Scientific Reports, 9(1). doi: 10.1038/s41598-019-53520-8

Oroz M, Begovac J, Planinić A, Rokić F, Lunar MM, Zorec TM, i sur.. Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia. Scientific Reports [Internet]. 21.11.2019. [pristupljeno 09.11.2024.];9(1). doi: 10.1038/s41598-019-53520-8

M. Oroz, et al., "Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia", Scientific Reports, vol. 9, br. 1, Studeni 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:445560. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:445560
Podaci o radu
Naslov (engleski)Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia
AutorMaja Oroz
AutorJosip Begovac
AutorAna Planinić
AutorFilip Rokić
AutorMaja M. Lunar
AutorTomaž Mark Zorec
AutorRobert Beluzić
AutorPetra Korać
AutorOliver Vugrek
AutorMario Poljak
AutorSnježana Židovec Lepej
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INFEKTOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
Abstract Molecular epidemiology of HIV-1 infection in treatment-naive HIV-1 infected persons from Croatia was investigated. We included 403 persons, representing 92.4% of all HIV-positive individuals entering clinical care in Croatia in 2014–2017. Overall prevalence of transmitted drug resistance (TDR) was estimated at 16.4%. Resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside RTI (NNRTIs) and protease inhibitors (PIs) was found in 11.4%, 6.7% and 2.5% of persons, respectively. Triple-class resistance was determined in 2.2% of individuals. In addition, a single case (1.0%) of resistance to integrase strand-transfer inhibitors (InSTIs) was found. Deep sequencing was performed on 48 randomly selected samples and detected additional TDR mutations in 6 cases. Phylogenetic inference showed that 347/403 sequences (86.1%) were part of transmission clusters and identified forward transmission of resistance in Croatia, even that of triple-class resistance. The largest TDR cluster of 53 persons with T215S was estimated to originate in the year 1992. Our data show a continuing need for pre-treatment HIV resistance testing in Croatia. Even though a low prevalence of resistance to InSTI was observed, surveillance of TDR to InSTI should be continued.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 9, br. 1, 17307
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-019-53520-8
URN:NBNurn:nbn:hr:105:445560
Datum objave publikacije2019-11-21
URL dokumentahttp://www.nature.com/articles/s41598-019-53520-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-02-15 12:04:38