prikaz prve stranice dokumenta Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery
  Download
PDF 993.31 KB
Scientific paper - Original scientific paper
Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery
Experimental and Clinical Endocrinology & Diabetes, 128 (2020), 11; 709-714. https://doi.org/10.1055/a-0885-1568
Škorić Polovina, Tanja; Kraljević, Ivana; Solak, Mirsala; Balasko, Annemarie; Haxhiu, Arta; Haxhiu, Arita; Dušek, Tina; Poljičanin, Tamara; Kaštelan, Darko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Škorić Polovina, T., Kraljević, I., Solak, M., Balasko, A., Haxhiu, A., Haxhiu, A. ... Kaštelan, D. (2020). Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery. Experimental and Clinical Endocrinology & Diabetes, 128. (11), 709-714. doi: 10.1055/a-0885-1568

Škorić Polovina, Tanja, et al. "Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery." Experimental and Clinical Endocrinology & Diabetes, vol. 128, no. 11, 2020, pp. 709-714. https://doi.org/10.1055/a-0885-1568

Škorić Polovina, Tanja, Ivana Kraljević, Mirsala Solak, Annemarie Balasko, Arta Haxhiu, Arita Haxhiu, Tina Dušek, Tamara Poljičanin and Darko Kaštelan. "Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery." Experimental and Clinical Endocrinology & Diabetes 128, no. 11 (2020): 709-714. https://doi.org/10.1055/a-0885-1568

Škorić Polovina, T., et al. (2020) 'Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery', Experimental and Clinical Endocrinology & Diabetes, 128(11), pp. 709-714. doi: 10.1055/a-0885-1568

Škorić Polovina T, Kraljević I, Solak M, Balasko A, Haxhiu A, Haxhiu A, and sur.. Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery. Experimental and Clinical Endocrinology & Diabetes [Internet]. 2020 November [cited 2024 November 26];128(11):709-714. doi: 10.1055/a-0885-1568

T. Škorić Polovina, et al., "Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery", Experimental and Clinical Endocrinology & Diabetes, vol. 128, no. 11, pp. 709-714, November 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:830150. [Accessed: 26 November 2024]

Metadata
Title (english)Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery
AuthorTanja Škorić Polovina
AuthorIvana Kraljević
AuthorMirsala Solak
AuthorAnnemarie Balasko
AuthorArta Haxhiu
AuthorArita Haxhiu
AuthorTina Dušek
AuthorTamara Poljičanin
AuthorDarko Kaštelan
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Purpose The purpose of this study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing the postoperative hypothalamic-pituitary-adrenal (HPA) axis function after pituitary tumor surgery. ----- Methods We performed a prospective observational study that enrolled 83 patients operated for pituitary adenoma or other sellar lesions at the University Hospital Center Zagreb between December 2013 and April 2017 (44 nonfunctioning pituitary adenomas, 28 somatotropinomas, 5 craniopharyngiomas, 2 prolactinomas resistant to medical therapy and 4 other lesions - Rathke's cleft cyst, arachnoid cyst, chondroma and gangliocytoma). Exclusion criteria were Cushing's disease, chronic therapy with glucocorticoids prior to surgery and preoperative adrenal insufficiency. Early postoperative basal cortisol levels (measured on the second postoperative day) and the Synacthen stimulation test (performed 3 months after the surgery with the peak cortisol level of>500 nmol/L considered as a normal response) were analyzed to assess HPA axis function during follow-up. ----- Results ROC analysis showed a cut-off of the basal cortisol level of ≥300 nmol/L measured on the second postoperative day to predict normal postoperative HPA axis function with the sensitivity of 92.31%, specificity of 87.14% and positive predictive value of 57.14%. ----- Conclusion The basal cortisol level on the second postoperative day is a valuable tool to predict integrity of the HPA axis after pituitary tumor surgery. Our data suggest that the cortisol level of ≥300 nmol/L accurately predicts adrenal sufficiency and that in these patients glucocorticoid therapy can be withdrawn.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleExperimental and Clinical Endocrinology & Diabetes
Numberingvol. 128, no. 11, pp. 709-714
p-ISSN0947-7349
e-ISSN1439-3646
DOIhttps://doi.org/10.1055/a-0885-1568
URN:NBNurn:nbn:hr:105:830150
Publication2020-11
Document URLhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-0885-1568
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2021-12-01
Terms of useLicence In copyright icon
Created on2021-02-17 10:03:00