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Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery
Experimental and Clinical Endocrinology & Diabetes, 128 (2020), 11; 709-714. https://doi.org/10.1055/a-0885-1568
Škorić Polovina, Tanja; Kraljević, Ivana; Solak, Mirsala; Balasko, Annemarie; Haxhiu, Arta; Haxhiu, Arita; Dušek, Tina; Poljičanin, Tamara; Kaštelan, Darko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Škorić Polovina, T., Kraljević, I., Solak, M., Balasko, A., Haxhiu, A., Haxhiu, A. ... Kaštelan, D. (2020). Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery. Experimental and Clinical Endocrinology & Diabetes, 128. (11), 709-714. doi: 10.1055/a-0885-1568

Škorić Polovina, Tanja, et al. "Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery." Experimental and Clinical Endocrinology & Diabetes, vol. 128, br. 11, 2020, str. 709-714. https://doi.org/10.1055/a-0885-1568

Škorić Polovina, Tanja, Ivana Kraljević, Mirsala Solak, Annemarie Balasko, Arta Haxhiu, Arita Haxhiu, Tina Dušek, Tamara Poljičanin i Darko Kaštelan. "Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery." Experimental and Clinical Endocrinology & Diabetes 128, br. 11 (2020): 709-714. https://doi.org/10.1055/a-0885-1568

Škorić Polovina, T., et al. (2020) 'Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery', Experimental and Clinical Endocrinology & Diabetes, 128(11), str. 709-714. doi: 10.1055/a-0885-1568

Škorić Polovina T, Kraljević I, Solak M, Balasko A, Haxhiu A, Haxhiu A, i sur.. Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery. Experimental and Clinical Endocrinology & Diabetes [Internet]. 11.2020. [pristupljeno 29.11.2024.];128(11):709-714. doi: 10.1055/a-0885-1568

T. Škorić Polovina, et al., "Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery", Experimental and Clinical Endocrinology & Diabetes, vol. 128, br. 11, str. 709-714, Studeni 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:830150. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:830150
Podaci o radu
Naslov (engleski)Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery
AutorTanja Škorić Polovina
AutorIvana Kraljević
AutorMirsala Solak
AutorAnnemarie Balasko
AutorArta Haxhiu
AutorArita Haxhiu
AutorTina Dušek
AutorTamara Poljičanin
AutorDarko Kaštelan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Purpose The purpose of this study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing the postoperative hypothalamic-pituitary-adrenal (HPA) axis function after pituitary tumor surgery. ----- Methods We performed a prospective observational study that enrolled 83 patients operated for pituitary adenoma or other sellar lesions at the University Hospital Center Zagreb between December 2013 and April 2017 (44 nonfunctioning pituitary adenomas, 28 somatotropinomas, 5 craniopharyngiomas, 2 prolactinomas resistant to medical therapy and 4 other lesions - Rathke's cleft cyst, arachnoid cyst, chondroma and gangliocytoma). Exclusion criteria were Cushing's disease, chronic therapy with glucocorticoids prior to surgery and preoperative adrenal insufficiency. Early postoperative basal cortisol levels (measured on the second postoperative day) and the Synacthen stimulation test (performed 3 months after the surgery with the peak cortisol level of>500 nmol/L considered as a normal response) were analyzed to assess HPA axis function during follow-up. ----- Results ROC analysis showed a cut-off of the basal cortisol level of ≥300 nmol/L measured on the second postoperative day to predict normal postoperative HPA axis function with the sensitivity of 92.31%, specificity of 87.14% and positive predictive value of 57.14%. ----- Conclusion The basal cortisol level on the second postoperative day is a valuable tool to predict integrity of the HPA axis after pituitary tumor surgery. Our data suggest that the cortisol level of ≥300 nmol/L accurately predicts adrenal sufficiency and that in these patients glucocorticoid therapy can be withdrawn.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaExperimental and Clinical Endocrinology & Diabetes
Brojčani podacivol. 128, br. 11, str. 709-714
p-ISSN0947-7349
e-ISSN1439-3646
DOIhttps://doi.org/10.1055/a-0885-1568
URN:NBNurn:nbn:hr:105:830150
Datum objave publikacije2020-11
URL dokumentahttp://www.thieme-connect.de/DOI/DOI?10.1055/a-0885-1568
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-12-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-02-17 10:03:00