prikaz prve stranice dokumenta Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave
  Download
PDF 335.56 KB
Scientific paper - Original scientific paper
Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave
Croatian Medical Journal, 61 (2020), 6; 491-500. https://doi.org/10.3325/cmj.2020.61.491
Krajcar, Nina; Stemberger Marić, Lorna; Šurina, Anja; Kurečić Filipović, Sanja; Trkulja, Vladimir; Roglić, Srđan; Tešović, Goran

Linked objects
COVID-19 | Virtual collection

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Krajcar, N., Stemberger Marić, L., Šurina, A., Kurečić Filipović, S., Trkulja, V., Roglić, S. & Tešović, G. (2020). Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave. Croatian Medical Journal, 61. (6), 491-500. doi: 10.3325/cmj.2020.61.491

Krajcar, Nina, et al. "Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave." Croatian Medical Journal, vol. 61, no. 6, 2020, pp. 491-500. https://doi.org/10.3325/cmj.2020.61.491

Krajcar, Nina, Lorna Stemberger Marić, Anja Šurina, Sanja Kurečić Filipović, Vladimir Trkulja, Srđan Roglić and Goran Tešović. "Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave." Croatian Medical Journal 61, no. 6 (2020): 491-500. https://doi.org/10.3325/cmj.2020.61.491

Krajcar, N., et al. (2020) 'Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave', Croatian Medical Journal, 61(6), pp. 491-500. doi: 10.3325/cmj.2020.61.491

Krajcar N, Stemberger Marić L, Šurina A, Kurečić Filipović S, Trkulja V, Roglić S, and sur.. Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave. Croatian Medical Journal [Internet]. 2020 December 31 [cited 2024 December 25];61(6):491-500. doi: 10.3325/cmj.2020.61.491

N. Krajcar, et al., "Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave", Croatian Medical Journal, vol. 61, no. 6, pp. 491-500, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:177121. [Accessed: 25 December 2024]

Metadata
Title (english)Epidemiological and clinical features of Croatian children and adolescents with a PCR-confirmed coronavirus disease 2019: differences between the first and second epidemic wave
AuthorNina Krajcar
AuthorLorna Stemberger Marić
AuthorAnja Šurina
AuthorSanja Kurečić Filipović
AuthorVladimir Trkulja
AuthorSrđan Roglić
AuthorGoran Tešović
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Aim: To describe epidemiological and clinical features of Croatian children and adolescents with a polymerase chain reaction (PCR)-confirmed coronavirus disease 2019. ----- Methods: Data on patients aged ≤19 years with a positive SARS-CoV-2 PCR test recorded in the period March 12-May 12 (first wave) and June 19-July 19, 2020 (second wave) were retrospectively analyzed. The periods were separated by several weeks with no incident cases. ----- Results: We analyzed data on 289 children and adolescents (6.5% of all cases; incidence rate [IR]=3.54, 95% confidence interval [CI] 3.14-3.97/million person-days), 124 in the first wave (IR=2.27) and 165 in the second wave (IR=6.37): IRR second/first=2.71 (2.13-3.44). During the first wave, the incidence was highest in infants (IR=3.48), while during the second wave it progressively increased to IR = 7.37 in 15-19-year olds. Family members were the key epidemiological contacts (72.6% cases), particularly during the first wave (95.8% vs 56.3%). Overall, 41.3% patients were asymptomatic, 25.3% in the first and 52.6% in the second wave. Age 15-19 years (vs younger) was associated with a higher (RR = 1.26, 1.02-1.54) and infection in the second wave with a lower probability (RR=0.66, 0.53-0.81) of being symptomatic. The most common symptoms were fever, cough, and rhinorrhea. In children aged ≥7 years, headache, anosmia/ageusia, and sore throat were also recorded. Only one child suffered a severe disease. All but 18 (7.8%) children were treated only symptomatically, and all fully recovered. ----- Conclusion: A large proportion of SARS-CoV-2 PCR-positive children/adolescents were asymptomatic. The associated disease was predominantly mild, comparably so in the first and second pandemic wave.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 61, no. 6, pp. 491-500
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2020.61.491
URN:NBNurn:nbn:hr:105:177121
Publication2020-12-31
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821366/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-02-25 08:34:59