prikaz prve stranice dokumenta Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes
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Scientific paper - Original scientific paper
Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes
Canadian Journal of Gastroenterology and Hepatology, 2021 (2021); 5582813. https://doi.org/10.1155/2021/5582813
Grgurević, Ivica; Salkić, Nermin; Mustapić, Sanda; Bokun, Tomislav; Podrug, Kristian; Marušić, Srećko; Rahelić, Dario; Matić, Tomas; Škurla, Viktoria; Mikolašević, Ivana

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Grgurević, I., Salkić, N., Mustapić, S., Bokun, T., Podrug, K., Marušić, S. ... Mikolašević, I. (2021). Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes. Canadian Journal of Gastroenterology and Hepatology, 2021.. doi: 10.1155/2021/5582813

Grgurević, Ivica, et al. "Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes." Canadian Journal of Gastroenterology and Hepatology, vol. 2021, 2021. https://doi.org/10.1155/2021/5582813

Grgurević, Ivica, Nermin Salkić, Sanda Mustapić, Tomislav Bokun, Kristian Podrug, Srećko Marušić, Dario Rahelić, Tomas Matić, Viktoria Škurla and Ivana Mikolašević. "Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes." Canadian Journal of Gastroenterology and Hepatology 2021 (2021). https://doi.org/10.1155/2021/5582813

Grgurević, I., et al. (2021) 'Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes', Canadian Journal of Gastroenterology and Hepatology, 2021. doi: 10.1155/2021/5582813

Grgurević I, Salkić N, Mustapić S, Bokun T, Podrug K, Marušić S, and sur.. Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes. Canadian Journal of Gastroenterology and Hepatology [Internet]. 2021 March 08 [cited 2024 November 29];2021. doi: 10.1155/2021/5582813

I. Grgurević, et al., "Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes", Canadian Journal of Gastroenterology and Hepatology, vol. 2021, March 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:158668. [Accessed: 29 November 2024]

Metadata
Title (english)Liver and Nonliver-Related Outcomes at 2 Years Are Not Influenced by the Results of the FIB-4 Test and Liver Elastography in a Real-Life Cohort of Patients with Type 2 Diabetes
AuthorIvica Grgurević
AuthorNermin Salkić
AuthorSanda Mustapić
AuthorTomislav Bokun
AuthorKristian Podrug
AuthorSrećko Marušić
AuthorDario Rahelić
AuthorTomas Matić
AuthorViktoria Škurla
AuthorIvana Mikolašević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims. To investigate morbidity and mortality in a real-life cohort of patients with type 2 diabetes (T2D) in relation to prevalence and severity of nonalcoholic fatty liver disease (NAFLD). ----- Methods. Patients with T2D were referred for assessment of liver fibrosis by the FIB-4 test and liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE). Liver steatosis was quantified by the controlled attenuation parameter (CAP). These patients were followed until death or censored date. ----- Results. Among 454 patients (52% males, mean age 62.5 years, BMI 30.9 kg/m2), 82.6% was overweight, 77.8% had fatty liver, and 9.9% and 3.1% had LSM and FIB-4 values suggestive of advanced fibrosis, respectively. During the follow-up period of median 2 years, 106 (23%) patients experienced adverse event (11% cardiovascular) and 17 (3.7%) died, whereas no liver-related morbidity or mortality was observed. Independent predictors of adverse outcomes were age and higher platelet count, while FIB-4, LSM, and CAP were not. ----- Conclusion. In a cohort of T2D patients, no liver-related morbidity or mortality occurred during 2 years. Our patients probably have low real prevalence of advanced fibrosis which is likely overestimated by LSM ≥ 9.6 kPa. Liver fibrosis may be safely reassessed in the 2 years interval in noncirrhotic patients with T2D.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCanadian Journal of Gastroenterology and Hepatology
Numberingvol. 2021, 5582813
p-ISSN2291-2789
e-ISSN2291-2797
DOIhttps://doi.org/10.1155/2021/5582813
URN:NBNurn:nbn:hr:105:158668
Publication2021-03-08
Document URLhttps://www.hindawi.com/journals/cjgh/2021/5582813/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-05-20 08:38:04