prikaz prve stranice dokumenta Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial
  Download
PDF 758.05 KB
Scientific paper - Original scientific paper
Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial
Frontiers in Pediatrics, 8 (2020); 553960. https://doi.org/10.3389/fped.2020.553960
Markovinović, Leo; Knezović, Ivica; Kniewald, Tihana; Stemberger Marić, Lorna; Trkulja, Vladimir; Tešović, Goran

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Markovinović, L., Knezović, I., Kniewald, T., Stemberger Marić, L., Trkulja, V. & Tešović, G. (2020). Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial. Frontiers in Pediatrics, 8.. doi: 10.3389/fped.2020.553960

Markovinović, Leo, et al. "Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial." Frontiers in Pediatrics, vol. 8, 2020. https://doi.org/10.3389/fped.2020.553960

Markovinović, Leo, Ivica Knezović, Tihana Kniewald, Lorna Stemberger Marić, Vladimir Trkulja and Goran Tešović. "Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial." Frontiers in Pediatrics 8 (2020). https://doi.org/10.3389/fped.2020.553960

Markovinović, L., et al. (2020) 'Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial', Frontiers in Pediatrics, 8. doi: 10.3389/fped.2020.553960

Markovinović L, Knezović I, Kniewald T, Stemberger Marić L, Trkulja V, Tešović G. Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial. Frontiers in Pediatrics [Internet]. 2020 December 21 [cited 2024 November 06];8. doi: 10.3389/fped.2020.553960

L. Markovinović, I. Knezović, T. Kniewald, L. Stemberger Marić, V. Trkulja and G. Tešović, "Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial", Frontiers in Pediatrics, vol. 8, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:857340. [Accessed: 06 November 2024]

Metadata
Title (english)Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial
AuthorLeo Markovinović
AuthorIvica Knezović
AuthorTihana Kniewald
AuthorLorna Stemberger Marić
AuthorVladimir Trkulja
AuthorGoran Tešović
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Purpose: The aim of this study was to compare two adjunct therapies in the treatment of childhood rotavirus gastroenteritis (RVGE). We compared the recommended treatment, probiotic Lactobacillus reuteri DSM 17938 (BioGaia®), vs. a novel treatment, enterosorbent polymethylsiloxane polyhydrate (Enterosgel®). Methods: This was an open-label, randomized, clinical controlled trial at the University Hospital for Infectious Diseases (UHID) in Zagreb, Croatia. A total of 149 children aged 6-36 months with acute rotaviral gastroenteritis over a period of <48 h, with no significant chronic comorbidity, were randomized to receive the standard therapy with L. reuteri DSM 17938 (hereafter L. reuteri) or polymethylsiloxane polyhydrate (hereafter PMSPH) therapy, during 5 days. The primary end point was time to recovery in days in both groups. The recovery was defined as absence of fever and vomiting and either the first firm stool, absence of stool for more than 24 h, or return of usual bowel habit. Results: A total of 75 children were randomized into the L. reuteri group and 74 were randomized into the PMSPH group; after excluding missing data, the data from 65 children in each group were analyzed. There was no significant difference in the treatment efficacy between the two regimens with an estimated median time of recovery of 6 days in both groups (p = 0.754). No significant side effects were observed in either group. Conclusion: Novel enterosorbent PMSPH had a similar efficacy to probiotic L. reuteri in the treatment of rotaviral gastroenteritis in preschool children.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Pediatrics
Numberingvol. 8, 553960
e-ISSN2296-2360
DOIhttps://doi.org/10.3389/fped.2020.553960
URN:NBNurn:nbn:hr:105:857340
Publication2020-12-21
Document URLhttps://www.frontiersin.org/articles/10.3389/fped.2020.553960/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-07-12 07:35:40