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Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial
Frontiers in Pediatrics, 8 (2020); 553960. https://doi.org/10.3389/fped.2020.553960
Markovinović, Leo; Knezović, Ivica; Kniewald, Tihana; Stemberger Marić, Lorna; Trkulja, Vladimir; Tešović, Goran

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Markovinović, L., Knezović, I., Kniewald, T., Stemberger Marić, L., Trkulja, V. i Tešović, G. (2020). Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial. Frontiers in Pediatrics, 8.. doi: 10.3389/fped.2020.553960

Markovinović, Leo, et al. "Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial." Frontiers in Pediatrics, vol. 8, 2020. https://doi.org/10.3389/fped.2020.553960

Markovinović, Leo, Ivica Knezović, Tihana Kniewald, Lorna Stemberger Marić, Vladimir Trkulja i Goran Tešović. "Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial." Frontiers in Pediatrics 8 (2020). https://doi.org/10.3389/fped.2020.553960

Markovinović, L., et al. (2020) 'Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial', Frontiers in Pediatrics, 8. doi: 10.3389/fped.2020.553960

Markovinović L, Knezović I, Kniewald T, Stemberger Marić L, Trkulja V, Tešović G. Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial. Frontiers in Pediatrics [Internet]. 21.12.2020. [pristupljeno 23.11.2024.];8. doi: 10.3389/fped.2020.553960

L. Markovinović, I. Knezović, T. Kniewald, L. Stemberger Marić, V. Trkulja i G. Tešović, "Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial", Frontiers in Pediatrics, vol. 8, Prosinac 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:857340. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:857340
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Naslov (engleski)Enteroadsorbent Polymethylsiloxane Polyhydrate vs. Probiotic Lactobacillus reuteri DSM 17938 in the Treatment of Rotaviral Gastroenteritis in Infants and Toddlers, a Randomized Controlled Trial
AutorLeo Markovinović
AutorIvica Knezović
AutorTihana Kniewald
AutorLorna Stemberger Marić
AutorVladimir Trkulja
AutorGoran Tešović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INFEKTOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Purpose: The aim of this study was to compare two adjunct therapies in the treatment of childhood rotavirus gastroenteritis (RVGE). We compared the recommended treatment, probiotic Lactobacillus reuteri DSM 17938 (BioGaia®), vs. a novel treatment, enterosorbent polymethylsiloxane polyhydrate (Enterosgel®). Methods: This was an open-label, randomized, clinical controlled trial at the University Hospital for Infectious Diseases (UHID) in Zagreb, Croatia. A total of 149 children aged 6-36 months with acute rotaviral gastroenteritis over a period of <48 h, with no significant chronic comorbidity, were randomized to receive the standard therapy with L. reuteri DSM 17938 (hereafter L. reuteri) or polymethylsiloxane polyhydrate (hereafter PMSPH) therapy, during 5 days. The primary end point was time to recovery in days in both groups. The recovery was defined as absence of fever and vomiting and either the first firm stool, absence of stool for more than 24 h, or return of usual bowel habit. Results: A total of 75 children were randomized into the L. reuteri group and 74 were randomized into the PMSPH group; after excluding missing data, the data from 65 children in each group were analyzed. There was no significant difference in the treatment efficacy between the two regimens with an estimated median time of recovery of 6 days in both groups (p = 0.754). No significant side effects were observed in either group. Conclusion: Novel enterosorbent PMSPH had a similar efficacy to probiotic L. reuteri in the treatment of rotaviral gastroenteritis in preschool children.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Pediatrics
Brojčani podacivol. 8, 553960
e-ISSN2296-2360
DOIhttps://doi.org/10.3389/fped.2020.553960
URN:NBNurn:nbn:hr:105:857340
Datum objave publikacije2020-12-21
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fped.2020.553960/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-07-12 07:35:40