prikaz prve stranice dokumenta Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
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Scientific paper - Original scientific paper
Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
Journal of Diabetes & Metabolic Disorders, 19 (2020), 2; 1185-1189. https://doi.org/10.1007/s40200-020-00620-2
Bulum, Tomislav; Tomić, Martina; Vučković-Rebrina, Sandra; Roso, Vinko; Vučić Lovrenčić, Marijana; Duvnjak, Lea

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Bulum, T., Tomić, M., Vučković Rebrina, S., Roso, V., Vučić Lovrenčić, M. & Duvnjak, L. (2020). Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels. Journal of Diabetes & Metabolic Disorders, 19. (2), 1185-1189. doi: 10.1007/s40200-020-00620-2

Bulum, Tomislav, et al. "Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels." Journal of Diabetes & Metabolic Disorders, vol. 19, no. 2, 2020, pp. 1185-1189. https://doi.org/10.1007/s40200-020-00620-2

Bulum, Tomislav, Martina Tomić, Sandra Vučković Rebrina, Vinko Roso, Marijana Vučić Lovrenčić and Lea Duvnjak. "Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels." Journal of Diabetes & Metabolic Disorders 19, no. 2 (2020): 1185-1189. https://doi.org/10.1007/s40200-020-00620-2

Bulum, T., et al. (2020) 'Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels', Journal of Diabetes & Metabolic Disorders, 19(2), pp. 1185-1189. doi: 10.1007/s40200-020-00620-2

Bulum T, Tomić M, Vučković Rebrina S, Roso V, Vučić Lovrenčić M, Duvnjak L. Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels. Journal of Diabetes & Metabolic Disorders [Internet]. 2020 August 29 [cited 2024 November 23];19(2):1185-1189. doi: 10.1007/s40200-020-00620-2

T. Bulum, M. Tomić, S. Vučković Rebrina, V. Roso, M. Vučić Lovrenčić and L. Duvnjak, "Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels", Journal of Diabetes & Metabolic Disorders, vol. 19, no. 2, pp. 1185-1189, August 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:819801. [Accessed: 23 November 2024]

Metadata
Title (english)Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
AuthorTomislav Bulum
AuthorMartina Tomić
AuthorSandra Vučković-Rebrina
AuthorVinko Roso
AuthorMarijana Vučić Lovrenčić
AuthorLea Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background and aims: Previous studies suggested that long-term perseverance of beta-cell function in patients with type 1 diabetes (T1DM) is associated with lower incidence of microvascular complications. The objective of this study was to evaluate preserved C-peptide secretion in patients with T1DM without overt chronic complications and to explore associations with resistin and uric acid as biomarkers of microvascular complication pathogenesis. ----- Materials and methods: We assessed residual beta-cell function in 164 T1DM patients (male/female = 91/73; age/diabetes duration range = 18-70/1-30 years) using an ultrasensitive C-peptide ELISA assay with detection limit of 2.5 pmol/L and total coefficient of variation (CV) 5,8% (Mercodia, Sweden). Serum level of uric acid was measured by enzymatic method (AU680, Beckman Coulter, USA) while resistin concentration was determined by the ELISA assay (Biovendor, Czech Republic). ----- Results: C-peptide secretors had shorter diabetes duration (5.1 vs. 16 years; p < 0,001), lower resistin (4.53 vs. 4.93 mg/mL p = 0.045), and higher uric acid (259 vs 238 μmol/L, p = 0.048) level than T1DM patients with no detectable C-peptide levels, while no differences in routine anthropometric and laboratory variables, including HbA1c, were observed. Although the proportion of C-peptide secretors significantly decreased across categories of diabetes duration (70%, 38%, 17% and 15% for <5, 5-10, 10-20 and 20-30 years of duration, respectively; p < 0,001), detectable C-peptide was found in 5/23 T1DM patients who were diagnosed with T1DM more than 20 years ago. ----- Conclusion: The results of our study revealed that patients with detectable C-peptide had lower resistin and higher uric acid level compared to patients with undetectable C-peptide.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Diabetes & Metabolic Disorders
Numberingvol. 19, no. 2, pp. 1185-1189
e-ISSN2251-6581
DOIhttps://doi.org/10.1007/s40200-020-00620-2
URN:NBNurn:nbn:hr:105:819801
Publication2020-08-29
Document URLhttps://link.springer.com/10.1007/s40200-020-00620-2
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-09-24 09:46:27