prikaz prve stranice dokumenta Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
  Preuzmi
PDF 206.29 KB
Znanstveni rad - Izvorni znanstveni rad
Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
Journal of Diabetes & Metabolic Disorders, 19 (2020), 2; 1185-1189. https://doi.org/10.1007/s40200-020-00620-2
Bulum, Tomislav; Tomić, Martina; Vučković-Rebrina, Sandra; Roso, Vinko; Vučić Lovrenčić, Marijana; Duvnjak, Lea

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Bulum, T., Tomić, M., Vučković Rebrina, S., Roso, V., Vučić Lovrenčić, M. i Duvnjak, L. (2020). Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels. Journal of Diabetes & Metabolic Disorders, 19. (2), 1185-1189. doi: 10.1007/s40200-020-00620-2

Bulum, Tomislav, et al. "Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels." Journal of Diabetes & Metabolic Disorders, vol. 19, br. 2, 2020, str. 1185-1189. https://doi.org/10.1007/s40200-020-00620-2

Bulum, Tomislav, Martina Tomić, Sandra Vučković Rebrina, Vinko Roso, Marijana Vučić Lovrenčić i Lea Duvnjak. "Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels." Journal of Diabetes & Metabolic Disorders 19, br. 2 (2020): 1185-1189. https://doi.org/10.1007/s40200-020-00620-2

Bulum, T., et al. (2020) 'Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels', Journal of Diabetes & Metabolic Disorders, 19(2), str. 1185-1189. doi: 10.1007/s40200-020-00620-2

Bulum T, Tomić M, Vučković Rebrina S, Roso V, Vučić Lovrenčić M, Duvnjak L. Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels. Journal of Diabetes & Metabolic Disorders [Internet]. 29.08.2020. [pristupljeno 23.11.2024.];19(2):1185-1189. doi: 10.1007/s40200-020-00620-2

T. Bulum, M. Tomić, S. Vučković Rebrina, V. Roso, M. Vučić Lovrenčić i L. Duvnjak, "Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels", Journal of Diabetes & Metabolic Disorders, vol. 19, br. 2, str. 1185-1189, Kolovoz 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:819801. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:819801
Podaci o radu
Naslov (engleski)Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
AutorTomislav Bulum
AutorMartina Tomić
AutorSandra Vučković-Rebrina
AutorVinko Roso
AutorMarijana Vučić Lovrenčić
AutorLea Duvnjak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background and aims: Previous studies suggested that long-term perseverance of beta-cell function in patients with type 1 diabetes (T1DM) is associated with lower incidence of microvascular complications. The objective of this study was to evaluate preserved C-peptide secretion in patients with T1DM without overt chronic complications and to explore associations with resistin and uric acid as biomarkers of microvascular complication pathogenesis. ----- Materials and methods: We assessed residual beta-cell function in 164 T1DM patients (male/female = 91/73; age/diabetes duration range = 18-70/1-30 years) using an ultrasensitive C-peptide ELISA assay with detection limit of 2.5 pmol/L and total coefficient of variation (CV) 5,8% (Mercodia, Sweden). Serum level of uric acid was measured by enzymatic method (AU680, Beckman Coulter, USA) while resistin concentration was determined by the ELISA assay (Biovendor, Czech Republic). ----- Results: C-peptide secretors had shorter diabetes duration (5.1 vs. 16 years; p < 0,001), lower resistin (4.53 vs. 4.93 mg/mL p = 0.045), and higher uric acid (259 vs 238 μmol/L, p = 0.048) level than T1DM patients with no detectable C-peptide levels, while no differences in routine anthropometric and laboratory variables, including HbA1c, were observed. Although the proportion of C-peptide secretors significantly decreased across categories of diabetes duration (70%, 38%, 17% and 15% for <5, 5-10, 10-20 and 20-30 years of duration, respectively; p < 0,001), detectable C-peptide was found in 5/23 T1DM patients who were diagnosed with T1DM more than 20 years ago. ----- Conclusion: The results of our study revealed that patients with detectable C-peptide had lower resistin and higher uric acid level compared to patients with undetectable C-peptide.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Diabetes & Metabolic Disorders
Brojčani podacivol. 19, br. 2, str. 1185-1189
e-ISSN2251-6581
DOIhttps://doi.org/10.1007/s40200-020-00620-2
URN:NBNurn:nbn:hr:105:819801
Datum objave publikacije2020-08-29
URL dokumentahttps://link.springer.com/10.1007/s40200-020-00620-2
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-09-24 09:46:27