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Scientific paper - Original scientific paper
Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network
Molecular Nutrition & Food Research, 65 (2021), 21; e2100400. https://doi.org/10.1002/mnfr.202100400
Homolak, Jan; Babić Perhoč, Ana; Knezović, Ana; Kodvanj, Ivan; Virag, Davor; Osmanović Barilar, Jelena; Riederer, Peter; Šalković‐Petrišić, Melita

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Homolak, J., Babić Perhoč, A., Knezović, A., Kodvanj, I., Virag, D., Osmanović Barilar, J. ... Šalković‐Petrišić, M. (2021). Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network. Molecular Nutrition & Food Research, 65. (21). doi: 10.1002/mnfr.202100400

Homolak, Jan, et al. "Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network." Molecular Nutrition & Food Research, vol. 65, no. 21, 2021. https://doi.org/10.1002/mnfr.202100400

Homolak, Jan, Ana Babić Perhoč, Ana Knezović, Ivan Kodvanj, Davor Virag, Jelena Osmanović Barilar, Peter Riederer and Melita Šalković‐Petrišić. "Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network." Molecular Nutrition & Food Research 65, no. 21 (2021). https://doi.org/10.1002/mnfr.202100400

Homolak, J., et al. (2021) 'Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network', Molecular Nutrition & Food Research, 65(21). doi: 10.1002/mnfr.202100400

Homolak J, Babić Perhoč A, Knezović A, Kodvanj I, Virag D, Osmanović Barilar J, and sur.. Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network. Molecular Nutrition & Food Research [Internet]. 2021 November [cited 2024 December 31];65(21). doi: 10.1002/mnfr.202100400

J. Homolak, et al., "Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network", Molecular Nutrition & Food Research, vol. 65, no. 21, November 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:039301. [Accessed: 31 December 2024]

Metadata
Title (english)Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network
AuthorJan Homolak https://orcid.org/0000-0003-1508-3243
AuthorAna Babić Perhoč
AuthorAna Knezović
AuthorIvan Kodvanj https://orcid.org/0000-0002-1359-3701
AuthorDavor Virag
AuthorJelena Osmanović Barilar
AuthorPeter Riederer
AuthorMelita Šalković‐Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Scope: Galactose, a ubiquitous monosaccharide with incompletely understood physiology is often exploited for inducing oxidative-stress mediated aging in animals. Recent research demonstrates that galactose can conserve cellular function during periods of starvation and prevent/alleviate cognitive deficits in a rat model of sporadic Alzheimer's disease. The present aim is to examine the acute effects of oral galactose on the redox regulatory network (RRN). ----- Methods and results: Rat plasma and hippocampal RRNs are analyzed upon acute orogastric gavage of galactose (200 mg kg-1 ). No systemic RRN disbalance is observed; however, a mild pro-oxidative shift accompanied by a paradoxical increment in tissue reductive capacity suggesting overcompensation of endogenous antioxidant systems is observed in the hippocampus. Galactose-induced increment of reductive capacity is accompanied by inflation of the hippocampal pool of nicotinamide adenine dinucleotide phosphates indicating ROS detoxification through disinhibition of the oxidative pentose phosphate pathway flux, reduced neuronal activity, and upregulation of Leloir pathway gatekeeper enzyme galactokinase-1. ----- Conclusion: Based on the observed findings, and in the context of previous work on galactose, a hormetic hypothesis of galactose is proposed suggesting that the protective effects may be inseparable from its pro-oxidative action at the biochemical level.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMolecular Nutrition & Food Research
Numberingvol. 65, no. 21, e2100400
p-ISSN1613-4125
e-ISSN1613-4133
DOIhttps://doi.org/10.1002/mnfr.202100400
URN:NBNurn:nbn:hr:105:039301
Publication2021-11
ProjectNumber: IP-2018-01-8938
Title (croatian): Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti
Acronym: NutrientGLP-1
Leader: Melita Šalković-Petrišić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100400
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2022-12-01
Terms of useLicence In copyright icon
Created on2021-11-16 12:19:33