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Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network
Molecular Nutrition & Food Research, 65 (2021), 21; e2100400. https://doi.org/10.1002/mnfr.202100400
Homolak, Jan; Babić Perhoč, Ana; Knezović, Ana; Kodvanj, Ivan; Virag, Davor; Osmanović Barilar, Jelena; Riederer, Peter; Šalković‐Petrišić, Melita

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Homolak, J., Babić Perhoč, A., Knezović, A., Kodvanj, I., Virag, D., Osmanović Barilar, J. ... Šalković‐Petrišić, M. (2021). Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network. Molecular Nutrition & Food Research, 65. (21). doi: 10.1002/mnfr.202100400

Homolak, Jan, et al. "Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network." Molecular Nutrition & Food Research, vol. 65, br. 21, 2021. https://doi.org/10.1002/mnfr.202100400

Homolak, Jan, Ana Babić Perhoč, Ana Knezović, Ivan Kodvanj, Davor Virag, Jelena Osmanović Barilar, Peter Riederer i Melita Šalković‐Petrišić. "Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network." Molecular Nutrition & Food Research 65, br. 21 (2021). https://doi.org/10.1002/mnfr.202100400

Homolak, J., et al. (2021) 'Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network', Molecular Nutrition & Food Research, 65(21). doi: 10.1002/mnfr.202100400

Homolak J, Babić Perhoč A, Knezović A, Kodvanj I, Virag D, Osmanović Barilar J, i sur.. Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network. Molecular Nutrition & Food Research [Internet]. 11.2021. [pristupljeno 29.12.2024.];65(21). doi: 10.1002/mnfr.202100400

J. Homolak, et al., "Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network", Molecular Nutrition & Food Research, vol. 65, br. 21, Studeni 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:039301. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:039301
Podaci o radu
Naslov (engleski)Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network
AutorJan Homolak https://orcid.org/0000-0003-1508-3243
AutorAna Babić Perhoč
AutorAna Knezović
AutorIvan Kodvanj https://orcid.org/0000-0002-1359-3701
AutorDavor Virag
AutorJelena Osmanović Barilar
AutorPeter Riederer
AutorMelita Šalković‐Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Scope: Galactose, a ubiquitous monosaccharide with incompletely understood physiology is often exploited for inducing oxidative-stress mediated aging in animals. Recent research demonstrates that galactose can conserve cellular function during periods of starvation and prevent/alleviate cognitive deficits in a rat model of sporadic Alzheimer's disease. The present aim is to examine the acute effects of oral galactose on the redox regulatory network (RRN). ----- Methods and results: Rat plasma and hippocampal RRNs are analyzed upon acute orogastric gavage of galactose (200 mg kg-1 ). No systemic RRN disbalance is observed; however, a mild pro-oxidative shift accompanied by a paradoxical increment in tissue reductive capacity suggesting overcompensation of endogenous antioxidant systems is observed in the hippocampus. Galactose-induced increment of reductive capacity is accompanied by inflation of the hippocampal pool of nicotinamide adenine dinucleotide phosphates indicating ROS detoxification through disinhibition of the oxidative pentose phosphate pathway flux, reduced neuronal activity, and upregulation of Leloir pathway gatekeeper enzyme galactokinase-1. ----- Conclusion: Based on the observed findings, and in the context of previous work on galactose, a hormetic hypothesis of galactose is proposed suggesting that the protective effects may be inseparable from its pro-oxidative action at the biochemical level.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMolecular Nutrition & Food Research
Brojčani podacivol. 65, br. 21, e2100400
p-ISSN1613-4125
e-ISSN1613-4133
DOIhttps://doi.org/10.1002/mnfr.202100400
URN:NBNurn:nbn:hr:105:039301
Datum objave publikacije2021-11
ProjektŠifra: IP-2018-01-8938
Naziv (hrvatski): Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti
Kratica: NutrientGLP-1
Voditelj: Melita Šalković-Petrišić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100400
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2022-12-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-11-16 12:19:33