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Scientific paper - Original scientific paper
The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
Journal of Alzheimer's Disease, 82 (2021), 2; 661-672. https://doi.org/10.3233/JAD-210158
Babić Leko, Mirjana; Jurasović, Jasna; Nikolac Perković, Matea; Španić, Ena; Sekovanić, Ankica; Orct, Tatjana; Lukinović Škudar, Vesna; Bačić Baronica, Koraljka; Kiđemet-Piskač, Spomenka; Vogrinc, Željka; Pivac, Nela; Borovečki, Fran; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Jurasović, J., Nikolac Perković, M., Španić, E., Sekovanić, A., Orct, T. ... Šimić, G. (2021). The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease. Journal of Alzheimer's Disease, 82. (2), 661-672. doi: 10.3233/JAD-210158

Babić Leko, Mirjana, et al. "The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease." Journal of Alzheimer's Disease, vol. 82, no. 2, 2021, pp. 661-672. https://doi.org/10.3233/JAD-210158

Babić Leko, Mirjana, Jasna Jurasović, Matea Nikolac Perković, Ena Španić, Ankica Sekovanić, Tatjana Orct, Vesna Lukinović Škudar, et al. "The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease." Journal of Alzheimer's Disease 82, no. 2 (2021): 661-672. https://doi.org/10.3233/JAD-210158

Babić Leko, M., et al. (2021) 'The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease', Journal of Alzheimer's Disease, 82(2), pp. 661-672. doi: 10.3233/JAD-210158

Babić Leko M, Jurasović J, Nikolac Perković M, Španić E, Sekovanić A, Orct T, and sur.. The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease. Journal of Alzheimer's Disease [Internet]. 2021 [cited 2024 November 30];82(2):661-672. doi: 10.3233/JAD-210158

M. Babić Leko, et al., "The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease", Journal of Alzheimer's Disease, vol. 82, no. 2, pp. 661-672, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:247939. [Accessed: 30 November 2024]

Metadata
Title (english)The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
AuthorMirjana Babić Leko
AuthorJasna Jurasović
AuthorMatea Nikolac Perković
AuthorEna Španić
AuthorAnkica Sekovanić
AuthorTatjana Orct
AuthorVesna Lukinović Škudar
AuthorKoraljka Bačić Baronica
AuthorSpomenka Kiđemet-Piskač
AuthorŽeljka Vogrinc
AuthorNela Pivac
AuthorFran Borovečki
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Abstract (english)
Background: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer's disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurodegeneration in AD through interaction with metals. Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity. ----- Objective: To test the association of essential metals with APOE genotype. ----- Methods: We compared plasma and cerebrospinal fluid (CSF) levels of copper, zinc, iron, sodium, magnesium, calcium, cobalt, molybdenum, manganese, boron, and chromium, and CSF ferritin levels among AD, mild cognitive impairment (MCI) patients, and healthy controls (HC) with different APOE genotype. ----- Results: Sodium, copper, and magnesium levels were increased in carriers of ɛ4 allele. Additionally, the increase in sodium, calcium and cobalt plasma levels was observed in carriers of ɛ4/ɛx genotype. The decrease in boron plasma levels was observed in carriers of ɛ4 allele and ɛ4/ɛ4 genotype. Additionally, CSF zinc levels as well as plasma sodium levels were increased in AD patients compared to HC. ----- Conclusion: These results indicate that the molecular underpinnings of association of essential metals and metalloids with APOE should be further tested and clarified in vivo and in vitro.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Alzheimer's Disease
Numberingvol. 82, no. 2, pp. 661-672
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-210158
URN:NBNurn:nbn:hr:105:247939
Publication2021
Document URLhttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-210158
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-01-11 11:29:23