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The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
Journal of Alzheimer's Disease, 82 (2021), 2; 661-672. https://doi.org/10.3233/JAD-210158
Babić Leko, Mirjana; Jurasović, Jasna; Nikolac Perković, Matea; Španić, Ena; Sekovanić, Ankica; Orct, Tatjana; Lukinović Škudar, Vesna; Bačić Baronica, Koraljka; Kiđemet-Piskač, Spomenka; Vogrinc, Željka; Pivac, Nela; Borovečki, Fran; Hof, Patrick R.; Šimić, Goran

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Babić Leko, M., Jurasović, J., Nikolac Perković, M., Španić, E., Sekovanić, A., Orct, T. ... Šimić, G. (2021). The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease. Journal of Alzheimer's Disease, 82. (2), 661-672. doi: 10.3233/JAD-210158

Babić Leko, Mirjana, et al. "The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease." Journal of Alzheimer's Disease, vol. 82, br. 2, 2021, str. 661-672. https://doi.org/10.3233/JAD-210158

Babić Leko, Mirjana, Jasna Jurasović, Matea Nikolac Perković, Ena Španić, Ankica Sekovanić, Tatjana Orct, Vesna Lukinović Škudar, et al. "The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease." Journal of Alzheimer's Disease 82, br. 2 (2021): 661-672. https://doi.org/10.3233/JAD-210158

Babić Leko, M., et al. (2021) 'The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease', Journal of Alzheimer's Disease, 82(2), str. 661-672. doi: 10.3233/JAD-210158

Babić Leko M, Jurasović J, Nikolac Perković M, Španić E, Sekovanić A, Orct T, i sur.. The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease. Journal of Alzheimer's Disease [Internet]. 2021. [pristupljeno 05.11.2024.];82(2):661-672. doi: 10.3233/JAD-210158

M. Babić Leko, et al., "The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease", Journal of Alzheimer's Disease, vol. 82, br. 2, str. 661-672, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:247939. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:247939
Podaci o radu
Naslov (engleski)The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
AutorMirjana Babić Leko
AutorJasna Jurasović
AutorMatea Nikolac Perković
AutorEna Španić
AutorAnkica Sekovanić
AutorTatjana Orct
AutorVesna Lukinović Škudar
AutorKoraljka Bačić Baronica
AutorSpomenka Kiđemet-Piskač
AutorŽeljka Vogrinc
AutorNela Pivac
AutorFran Borovečki
AutorPatrick R. Hof
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Sažetak (engleski)
Background: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer's disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurodegeneration in AD through interaction with metals. Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity. ----- Objective: To test the association of essential metals with APOE genotype. ----- Methods: We compared plasma and cerebrospinal fluid (CSF) levels of copper, zinc, iron, sodium, magnesium, calcium, cobalt, molybdenum, manganese, boron, and chromium, and CSF ferritin levels among AD, mild cognitive impairment (MCI) patients, and healthy controls (HC) with different APOE genotype. ----- Results: Sodium, copper, and magnesium levels were increased in carriers of ɛ4 allele. Additionally, the increase in sodium, calcium and cobalt plasma levels was observed in carriers of ɛ4/ɛx genotype. The decrease in boron plasma levels was observed in carriers of ɛ4 allele and ɛ4/ɛ4 genotype. Additionally, CSF zinc levels as well as plasma sodium levels were increased in AD patients compared to HC. ----- Conclusion: These results indicate that the molecular underpinnings of association of essential metals and metalloids with APOE should be further tested and clarified in vivo and in vitro.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Alzheimer's Disease
Brojčani podacivol. 82, br. 2, str. 661-672
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-210158
URN:NBNurn:nbn:hr:105:247939
Datum objave publikacije2021
URL dokumentahttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-210158
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-01-11 11:29:23