prikaz prve stranice dokumenta Dishevelled family proteins (DVL1-3) expression in IUGR placentas
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Scientific paper - Original scientific paper
Dishevelled family proteins (DVL1-3) expression in IUGR placentas
Bosnian Journal of Basic Medical Sciences, 21 (2021), 4; 447-453. https://doi.org/10.17305/bjbms.2020.5422
Šola, Ida Marija; Šerman, Alan; Karin-Kujundžić, Valentina; Paić, Frane; Škrtić, Anita; Slatina, Paula; Kakarigi, Luka; Vranić, Semir; Šerman, Ljiljana

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Šola, I. M., Šerman, A., Karin Kujundžić, V., Paić, F., Škrtić, A., Slatina, P. ... Šerman, Lj. (2021). Dishevelled family proteins (DVL1-3) expression in IUGR placentas. Bosnian Journal of Basic Medical Sciences, 21. (4), 447-453. doi: 10.17305/bjbms.2020.5422

Šola, Ida Marija, et al. "Dishevelled family proteins (DVL1-3) expression in IUGR placentas." Bosnian Journal of Basic Medical Sciences, vol. 21, no. 4, 2021, pp. 447-453. https://doi.org/10.17305/bjbms.2020.5422

Šola, Ida Marija, Alan Šerman, Valentina Karin Kujundžić, Frane Paić, Anita Škrtić, Paula Slatina, Luka Kakarigi, Semir Vranić and Ljiljana Šerman. "Dishevelled family proteins (DVL1-3) expression in IUGR placentas." Bosnian Journal of Basic Medical Sciences 21, no. 4 (2021): 447-453. https://doi.org/10.17305/bjbms.2020.5422

Šola, I. M., et al. (2021) 'Dishevelled family proteins (DVL1-3) expression in IUGR placentas', Bosnian Journal of Basic Medical Sciences, 21(4), pp. 447-453. doi: 10.17305/bjbms.2020.5422

Šola IM, Šerman A, Karin Kujundžić V, Paić F, Škrtić A, Slatina P, and sur.. Dishevelled family proteins (DVL1-3) expression in IUGR placentas. Bosnian Journal of Basic Medical Sciences [Internet]. 2021 August 01 [cited 2024 December 24];21(4):447-453. doi: 10.17305/bjbms.2020.5422

I. M. Šola, et al., "Dishevelled family proteins (DVL1-3) expression in IUGR placentas", Bosnian Journal of Basic Medical Sciences, vol. 21, no. 4, pp. 447-453, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:008237. [Accessed: 24 December 2024]

Metadata
Title (english)Dishevelled family proteins (DVL1-3) expression in IUGR placentas
AuthorIda Marija Šola
AuthorAlan Šerman
AuthorValentina Karin-Kujundžić
AuthorFrane Paić
AuthorAnita Škrtić
AuthorPaula Slatina
AuthorLuka Kakarigi
AuthorSemir Vranić
AuthorLjiljana Šerman
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important in embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in naturally invasive tissue, trophoblast. Formalin-fixed paraffin-embedded samples of 15 term placentas from physiologic term pregnancies and 15 term placentas from pregnancies complicated with intrauterine growth restrictions (IUGR) were used for the study. Expression levels of mRNA for DVL1, DVL2, and DVL3 in placentas were analyzed by quantitative real-time PCR (qRT-PCR). DVL1, DVL2, and DVL3 protein expression were semi-quantitatively analyzed using immunohistochemistry. The expression of DVL2 and DVL3 proteins was significantly higher in trophoblasts in placental villi from IUGR pregnancies compared with the control group of term placentas. In contrast, DVL3 protein expression was significantly higher in endothelial cells in placental villi from IUGR pregnancies compared with normal term placentas. The observed differences at protein levels between normal and IUGR placentas were not confirmed at the mRNA levels of DVL genes. Our data indicate the active involvement of DVL proteins in IUGR-related placentas. No significant changes were observed in DVL mRNA levels between the two groups of placentas. Further studies are required to explore the clinical relevance of these observations.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 21, no. 4, pp. 447-453
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2020.5422
URN:NBNurn:nbn:hr:105:008237
Publication2021-08-01
Document URLhttp://www.bjbms.org/ojs/index.php/bjbms/article/view/5422
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-08 08:18:03