prikaz prve stranice dokumenta Dishevelled family proteins (DVL1-3) expression in IUGR placentas
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Dishevelled family proteins (DVL1-3) expression in IUGR placentas
Bosnian Journal of Basic Medical Sciences, 21 (2021), 4; 447-453. https://doi.org/10.17305/bjbms.2020.5422
Šola, Ida Marija; Šerman, Alan; Karin-Kujundžić, Valentina; Paić, Frane; Škrtić, Anita; Slatina, Paula; Kakarigi, Luka; Vranić, Semir; Šerman, Ljiljana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Šola, I. M., Šerman, A., Karin Kujundžić, V., Paić, F., Škrtić, A., Slatina, P. ... Šerman, Lj. (2021). Dishevelled family proteins (DVL1-3) expression in IUGR placentas. Bosnian Journal of Basic Medical Sciences, 21. (4), 447-453. doi: 10.17305/bjbms.2020.5422

Šola, Ida Marija, et al. "Dishevelled family proteins (DVL1-3) expression in IUGR placentas." Bosnian Journal of Basic Medical Sciences, vol. 21, br. 4, 2021, str. 447-453. https://doi.org/10.17305/bjbms.2020.5422

Šola, Ida Marija, Alan Šerman, Valentina Karin Kujundžić, Frane Paić, Anita Škrtić, Paula Slatina, Luka Kakarigi, Semir Vranić i Ljiljana Šerman. "Dishevelled family proteins (DVL1-3) expression in IUGR placentas." Bosnian Journal of Basic Medical Sciences 21, br. 4 (2021): 447-453. https://doi.org/10.17305/bjbms.2020.5422

Šola, I. M., et al. (2021) 'Dishevelled family proteins (DVL1-3) expression in IUGR placentas', Bosnian Journal of Basic Medical Sciences, 21(4), str. 447-453. doi: 10.17305/bjbms.2020.5422

Šola IM, Šerman A, Karin Kujundžić V, Paić F, Škrtić A, Slatina P, i sur.. Dishevelled family proteins (DVL1-3) expression in IUGR placentas. Bosnian Journal of Basic Medical Sciences [Internet]. 01.08.2021. [pristupljeno 28.04.2024.];21(4):447-453. doi: 10.17305/bjbms.2020.5422

I. M. Šola, et al., "Dishevelled family proteins (DVL1-3) expression in IUGR placentas", Bosnian Journal of Basic Medical Sciences, vol. 21, br. 4, str. 447-453, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:008237. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:008237
Podaci o radu
Naslov (engleski)Dishevelled family proteins (DVL1-3) expression in IUGR placentas
AutorIda Marija Šola
AutorAlan Šerman
AutorValentina Karin-Kujundžić
AutorFrane Paić
AutorAnita Škrtić
AutorPaula Slatina
AutorLuka Kakarigi
AutorSemir Vranić
AutorLjiljana Šerman
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important in embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in naturally invasive tissue, trophoblast. Formalin-fixed paraffin-embedded samples of 15 term placentas from physiologic term pregnancies and 15 term placentas from pregnancies complicated with intrauterine growth restrictions (IUGR) were used for the study. Expression levels of mRNA for DVL1, DVL2, and DVL3 in placentas were analyzed by quantitative real-time PCR (qRT-PCR). DVL1, DVL2, and DVL3 protein expression were semi-quantitatively analyzed using immunohistochemistry. The expression of DVL2 and DVL3 proteins was significantly higher in trophoblasts in placental villi from IUGR pregnancies compared with the control group of term placentas. In contrast, DVL3 protein expression was significantly higher in endothelial cells in placental villi from IUGR pregnancies compared with normal term placentas. The observed differences at protein levels between normal and IUGR placentas were not confirmed at the mRNA levels of DVL genes. Our data indicate the active involvement of DVL proteins in IUGR-related placentas. No significant changes were observed in DVL mRNA levels between the two groups of placentas. Further studies are required to explore the clinical relevance of these observations.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBosnian Journal of Basic Medical Sciences
Brojčani podacivol. 21, br. 4, str. 447-453
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2020.5422
URN:NBNurn:nbn:hr:105:008237
Datum objave publikacije2021-08-01
URL dokumentahttp://www.bjbms.org/ojs/index.php/bjbms/article/view/5422
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-08 08:18:03