prikaz prve stranice dokumenta Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
  Download
PDF 1.19 MB
Scientific paper - Original scientific paper
Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
Antioxidants, 10 (2021), 9; 1341. https://doi.org/10.3390/antiox10091341
Žarković, Neven; Orehovec, Biserka; Milković, Lidija; Baršić, Bruno; Tatzber, Franz; Wonisch, Willibald; Tarle, Marko; Kmet, Marta; Mataić, Ana; Jakovčević, Antonia; Vuković, Tea; Talić, Danijela; Waeg, Georg; Lukšić, Ivica; Skrzydlewska, Elzbieta; Žarković, Kamelija More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Žarković, N., Orehovec, B., Milković, L., Baršić, B., Tatzber, F., Wonisch, W. ... Žarković, K. (2021). Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19. Antioxidants, 10. (9). doi: 10.3390/antiox10091341

Žarković, Neven, et al. "Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19." Antioxidants, vol. 10, no. 9, 2021. https://doi.org/10.3390/antiox10091341

Žarković, Neven, Biserka Orehovec, Lidija Milković, Bruno Baršić, Franz Tatzber, Willibald Wonisch, Marko Tarle, et al. "Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19." Antioxidants 10, no. 9 (2021). https://doi.org/10.3390/antiox10091341

Žarković, N., et al. (2021) 'Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19', Antioxidants, 10(9). doi: 10.3390/antiox10091341

Žarković N, Orehovec B, Milković L, Baršić B, Tatzber F, Wonisch W, and sur.. Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19. Antioxidants [Internet]. 2021 August 25 [cited 2024 November 09];10(9). doi: 10.3390/antiox10091341

N. Žarković, et al., "Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19", Antioxidants, vol. 10, no. 9, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:586613. [Accessed: 09 November 2024]

Metadata
Title (english)Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
AuthorNeven Žarković
AuthorBiserka Orehovec
AuthorLidija Milković
AuthorBruno Baršić
AuthorFranz Tatzber
AuthorWillibald Wonisch
AuthorMarko Tarle
AuthorMarta Kmet
AuthorAna Mataić
AuthorAntonia Jakovčević
AuthorTea Vuković
AuthorDanijela Talić
AuthorGeorg Waeg
AuthorIvica Lukšić
AuthorElzbieta Skrzydlewska
AuthorKamelija Žarković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Major findings of the pilot study involving 21 critically ill patients during the week after admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients have recovered, while seven passed away. There were no differences between them in respect to clinical or laboratory parameters monitored. However, protein adducts of the lipid peroxidation product 4-hydroxynonenal (HNE) were higher in the plasma of the deceased patients, while total antioxidant capacity was below the detection limit for the majority of sera samples in both groups. Moreover, levels of the HNE-protein adducts were constant in the plasma of the deceased patients, while in survivors, they have shown prominent and dynamic variations, suggesting that survivors had active oxidative stress response mechanisms reacting to COVID-19 aggression, which were not efficient in patients who died. Immunohistochemistry revealed the abundant presence of HNE-protein adducts in the lungs of deceased patients indicating that HNE is associated with the lethal outcome. It seems that HNE was spreading from the blood vessels more than being a consequence of pneumonia. Due to the limitations of the relatively small number of patients involved in this study, further research on HNE and antioxidants is needed. This might allow a better understanding of COVID-19 and options for utilizing antioxidants by personalized, integrative biomedicine approach to prevent the onset of HNE-mediated vitious circle of lipid peroxidation in patients with aggressive inflammatory diseases.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAntioxidants
Numberingvol. 10, no. 9, 1341
e-ISSN2076-3921
DOIhttps://doi.org/10.3390/antiox10091341
URN:NBNurn:nbn:hr:105:586613
Publication2021-08-25
Document URLhttps://www.mdpi.com/2076-3921/10/9/1341
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-04-21 07:44:00