prikaz prve stranice dokumenta Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
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Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
Antioxidants, 10 (2021), 9; 1341. https://doi.org/10.3390/antiox10091341
Žarković, Neven; Orehovec, Biserka; Milković, Lidija; Baršić, Bruno; Tatzber, Franz; Wonisch, Willibald; Tarle, Marko; Kmet, Marta; Mataić, Ana; Jakovčević, Antonia; Vuković, Tea; Talić, Danijela; Waeg, Georg; Lukšić, Ivica; Skrzydlewska, Elzbieta; Žarković, Kamelija Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Žarković, N., Orehovec, B., Milković, L., Baršić, B., Tatzber, F., Wonisch, W. ... Žarković, K. (2021). Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19. Antioxidants, 10. (9). doi: 10.3390/antiox10091341

Žarković, Neven, et al. "Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19." Antioxidants, vol. 10, br. 9, 2021. https://doi.org/10.3390/antiox10091341

Žarković, Neven, Biserka Orehovec, Lidija Milković, Bruno Baršić, Franz Tatzber, Willibald Wonisch, Marko Tarle, et al. "Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19." Antioxidants 10, br. 9 (2021). https://doi.org/10.3390/antiox10091341

Žarković, N., et al. (2021) 'Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19', Antioxidants, 10(9). doi: 10.3390/antiox10091341

Žarković N, Orehovec B, Milković L, Baršić B, Tatzber F, Wonisch W, i sur.. Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19. Antioxidants [Internet]. 25.08.2021. [pristupljeno 24.12.2024.];10(9). doi: 10.3390/antiox10091341

N. Žarković, et al., "Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19", Antioxidants, vol. 10, br. 9, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:586613. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:586613
Podaci o radu
Naslov (engleski)Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
AutorNeven Žarković
AutorBiserka Orehovec
AutorLidija Milković
AutorBruno Baršić
AutorFranz Tatzber
AutorWillibald Wonisch
AutorMarko Tarle
AutorMarta Kmet
AutorAna Mataić
AutorAntonia Jakovčević
AutorTea Vuković
AutorDanijela Talić
AutorGeorg Waeg
AutorIvica Lukšić
AutorElzbieta Skrzydlewska
AutorKamelija Žarković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Major findings of the pilot study involving 21 critically ill patients during the week after admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients have recovered, while seven passed away. There were no differences between them in respect to clinical or laboratory parameters monitored. However, protein adducts of the lipid peroxidation product 4-hydroxynonenal (HNE) were higher in the plasma of the deceased patients, while total antioxidant capacity was below the detection limit for the majority of sera samples in both groups. Moreover, levels of the HNE-protein adducts were constant in the plasma of the deceased patients, while in survivors, they have shown prominent and dynamic variations, suggesting that survivors had active oxidative stress response mechanisms reacting to COVID-19 aggression, which were not efficient in patients who died. Immunohistochemistry revealed the abundant presence of HNE-protein adducts in the lungs of deceased patients indicating that HNE is associated with the lethal outcome. It seems that HNE was spreading from the blood vessels more than being a consequence of pneumonia. Due to the limitations of the relatively small number of patients involved in this study, further research on HNE and antioxidants is needed. This might allow a better understanding of COVID-19 and options for utilizing antioxidants by personalized, integrative biomedicine approach to prevent the onset of HNE-mediated vitious circle of lipid peroxidation in patients with aggressive inflammatory diseases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAntioxidants
Brojčani podacivol. 10, br. 9, 1341
e-ISSN2076-3921
DOIhttps://doi.org/10.3390/antiox10091341
URN:NBNurn:nbn:hr:105:586613
Datum objave publikacije2021-08-25
URL dokumentahttps://www.mdpi.com/2076-3921/10/9/1341
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-21 07:44:00