prikaz prve stranice dokumenta Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease
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Scientific paper - Original scientific paper
Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease
Current Alzheimer Research, 18 (2021), 7; 585-594. https://doi.org/10.2174/1567205018666210917162843
Babić Leko, Mirjana; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Nikolac Perković, M., Nedić Erjavec, G., Klepac, N., Švob Štrac, D., Borovečki, F. ... Šimić, G. (2021). Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease. Current Alzheimer Research, 18. (7), 585-594. doi: 10.2174/1567205018666210917162843

Babić Leko, Mirjana, et al. "Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease." Current Alzheimer Research, vol. 18, no. 7, 2021, pp. 585-594. https://doi.org/10.2174/1567205018666210917162843

Babić Leko, Mirjana, Matea Nikolac Perković, Gordana Nedić Erjavec, Nataša Klepac, Dubravka Švob Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof and Goran Šimić. "Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease." Current Alzheimer Research 18, no. 7 (2021): 585-594. https://doi.org/10.2174/1567205018666210917162843

Babić Leko, M., et al. (2021) 'Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease', Current Alzheimer Research, 18(7), pp. 585-594. doi: 10.2174/1567205018666210917162843

Babić Leko M, Nikolac Perković M, Nedić Erjavec G, Klepac N, Švob Štrac D, Borovečki F, and sur.. Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease. Current Alzheimer Research [Internet]. 2021 June [cited 2024 December 30];18(7):585-594. doi: 10.2174/1567205018666210917162843

M. Babić Leko, et al., "Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease", Current Alzheimer Research, vol. 18, no. 7, pp. 585-594, June 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:989394. [Accessed: 30 December 2024]

Metadata
Title (english)Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease
AuthorMirjana Babić Leko
AuthorMatea Nikolac Perković
AuthorGordana Nedić Erjavec
AuthorNataša Klepac
AuthorDubravka Švob Štrac
AuthorFran Borovečki
AuthorNela Pivac
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Background: The dopaminergic system is functionally compromised in Alzheimer's Disease (AD). The activity of Monoamine Oxidase B (MAOB), the enzyme involved in the degradation of dopamine, is increased during AD. Also, increased expression of MAOB occurs in the postmortem hippocampus and neocortex of patients with AD. The MAOB rs1799836 polymorphism modulates MAOB transcription, consequently influencing protein translation and MAOB activity. We recently showed that cerebrospinal fluid levels of amyloid β1-42 are decreased in patients carrying the A allele in MAOB rs1799836 polymorphism. ----- Objective: The present study compares MAOB rs1799836 polymorphism and APOE, the only confirmed genetic risk factor for sporadic AD. ----- Methods: We included 253 participants, 127 of whom had AD, 57 had mild cognitive impairment, 11 were healthy controls, and 58 suffered from other primary causes of dementia. MAOB and APOE polymorphisms were determined using TaqMan SNP Genotyping Assays. ----- Results: We observed that the frequency of APOE ε4/ε4 homozygotes and APOE ε4 carriers is significantly increased among patients carrying the AA MAOB rs1799836 genotype. ----- Conclusion: These results indicate that the MAOB rs1799836 polymorphism is a potential genetic biomarker of AD and a potential target for the treatment of decreased dopaminergic transmission and cognitive deterioration in AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCurrent Alzheimer Research
Numberingvol. 18, no. 7, pp. 585-594
p-ISSN1567-2050
e-ISSN1875-5828
DOIhttps://doi.org/10.2174/1567205018666210917162843
URN:NBNurn:nbn:hr:105:989394
Publication2021-06
ProjectNumber: IP-2019-04-3584
Title (croatian): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Title (english): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Acronym: ALZ-BBB-INNATETAU
Leader: Goran Šimić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.eurekaselect.com/196621/article
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2022-07-01
Terms of useLicence In copyright icon
Created on2022-04-28 10:47:51