prikaz prve stranice dokumenta Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease
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Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease
Current Alzheimer Research, 18 (2021), 7; 585-594. https://doi.org/10.2174/1567205018666210917162843
Babić Leko, Mirjana; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Babić Leko, M., Nikolac Perković, M., Nedić Erjavec, G., Klepac, N., Švob Štrac, D., Borovečki, F. ... Šimić, G. (2021). Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease. Current Alzheimer Research, 18. (7), 585-594. doi: 10.2174/1567205018666210917162843

Babić Leko, Mirjana, et al. "Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease." Current Alzheimer Research, vol. 18, br. 7, 2021, str. 585-594. https://doi.org/10.2174/1567205018666210917162843

Babić Leko, Mirjana, Matea Nikolac Perković, Gordana Nedić Erjavec, Nataša Klepac, Dubravka Švob Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof i Goran Šimić. "Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease." Current Alzheimer Research 18, br. 7 (2021): 585-594. https://doi.org/10.2174/1567205018666210917162843

Babić Leko, M., et al. (2021) 'Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease', Current Alzheimer Research, 18(7), str. 585-594. doi: 10.2174/1567205018666210917162843

Babić Leko M, Nikolac Perković M, Nedić Erjavec G, Klepac N, Švob Štrac D, Borovečki F, i sur.. Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease. Current Alzheimer Research [Internet]. 06.2021. [pristupljeno 19.04.2024.];18(7):585-594. doi: 10.2174/1567205018666210917162843

M. Babić Leko, et al., "Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease", Current Alzheimer Research, vol. 18, br. 7, str. 585-594, Lipanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:989394. [Citirano: 19.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:989394
Podaci o radu
Naslov (engleski)Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease
AutorMirjana Babić Leko
AutorMatea Nikolac Perković
AutorGordana Nedić Erjavec
AutorNataša Klepac
AutorDubravka Švob Štrac
AutorFran Borovečki
AutorNela Pivac
AutorPatrick R. Hof
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Background: The dopaminergic system is functionally compromised in Alzheimer's Disease (AD). The activity of Monoamine Oxidase B (MAOB), the enzyme involved in the degradation of dopamine, is increased during AD. Also, increased expression of MAOB occurs in the postmortem hippocampus and neocortex of patients with AD. The MAOB rs1799836 polymorphism modulates MAOB transcription, consequently influencing protein translation and MAOB activity. We recently showed that cerebrospinal fluid levels of amyloid β1-42 are decreased in patients carrying the A allele in MAOB rs1799836 polymorphism. ----- Objective: The present study compares MAOB rs1799836 polymorphism and APOE, the only confirmed genetic risk factor for sporadic AD. ----- Methods: We included 253 participants, 127 of whom had AD, 57 had mild cognitive impairment, 11 were healthy controls, and 58 suffered from other primary causes of dementia. MAOB and APOE polymorphisms were determined using TaqMan SNP Genotyping Assays. ----- Results: We observed that the frequency of APOE ε4/ε4 homozygotes and APOE ε4 carriers is significantly increased among patients carrying the AA MAOB rs1799836 genotype. ----- Conclusion: These results indicate that the MAOB rs1799836 polymorphism is a potential genetic biomarker of AD and a potential target for the treatment of decreased dopaminergic transmission and cognitive deterioration in AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Alzheimer Research
Brojčani podacivol. 18, br. 7, str. 585-594
p-ISSN1567-2050
e-ISSN1875-5828
DOIhttps://doi.org/10.2174/1567205018666210917162843
URN:NBNurn:nbn:hr:105:989394
Datum objave publikacije2021-06
ProjektŠifra: IP-2019-04-3584
Naziv (hrvatski): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Naziv (engleski): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Kratica: ALZ-BBB-INNATETAU
Voditelj: Goran Šimić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.eurekaselect.com/196621/article
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2022-07-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-28 10:47:51