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Scientific paper - Original scientific paper
The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia
Current Issues in Molecular Biology, 43 (2021), 2; 618-636. https://doi.org/10.3390/cimb43020045
Madžarac, Zoran; Tudor, Lucija; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Pivac, Nela

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Madžarac, Z., Tudor, L., Šagud, M., Nedić Erjavec, G., Mihaljević Peleš, A. & Pivac, N. (2021). The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia. Current Issues in Molecular Biology, 43. (2), 618-636. doi: 10.3390/cimb43020045

Madžarac, Zoran, et al. "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia." Current Issues in Molecular Biology, vol. 43, no. 2, 2021, pp. 618-636. https://doi.org/10.3390/cimb43020045

Madžarac, Zoran, Lucija Tudor, Marina Šagud, Gordana Nedić Erjavec, Alma Mihaljević Peleš and Nela Pivac. "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia." Current Issues in Molecular Biology 43, no. 2 (2021): 618-636. https://doi.org/10.3390/cimb43020045

Madžarac, Z., et al. (2021) 'The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia', Current Issues in Molecular Biology, 43(2), pp. 618-636. doi: 10.3390/cimb43020045

Madžarac Z, Tudor L, Šagud M, Nedić Erjavec G, Mihaljević Peleš A, Pivac N. The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia. Current Issues in Molecular Biology [Internet]. 2021 July 08 [cited 2024 December 26];43(2):618-636. doi: 10.3390/cimb43020045

Z. Madžarac, L. Tudor, M. Šagud, G. Nedić Erjavec, A. Mihaljević Peleš and N. Pivac, "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia", Current Issues in Molecular Biology, vol. 43, no. 2, pp. 618-636, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:238298. [Accessed: 26 December 2024]

Metadata
Title (english)The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia
AuthorZoran Madžarac
AuthorLucija Tudor
AuthorMarina Šagud
AuthorGordana Nedić Erjavec
AuthorAlma Mihaljević Peleš
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations were detected in a research sample of 302 patients with schizophrenia. In female patients with schizophrenia, the presence of the G allele or GG genotype of COMT rs4680 and rs4818, as well as GG haplotype rs4818-rs4680, which were all related to higher COMT activity, was associated with an increase in several dimensions of negative symptoms and anhedonia. In male patients with schizophrenia, carriers of the MAO-B rs1799836 A allele, presumably associated with higher MAO-B activity, had a higher severity of alogia, while carriers of the A allele of the MAO-B rs6651806 had a higher severity of negative symptoms. These findings suggest that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCurrent Issues in Molecular Biology
Numberingvol. 43, no. 2, pp. 618-636
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb43020045
URN:NBNurn:nbn:hr:105:238298
Publication2021-07-08
Document URLhttps://www.mdpi.com/1467-3045/43/2/45
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-09 09:10:26