prikaz prve stranice dokumenta The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia
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The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia
Current Issues in Molecular Biology, 43 (2021), 2; 618-636. https://doi.org/10.3390/cimb43020045
Madžarac, Zoran; Tudor, Lucija; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Madžarac, Z., Tudor, L., Šagud, M., Nedić Erjavec, G., Mihaljević Peleš, A. i Pivac, N. (2021). The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia. Current Issues in Molecular Biology, 43. (2), 618-636. doi: 10.3390/cimb43020045

Madžarac, Zoran, et al. "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia." Current Issues in Molecular Biology, vol. 43, br. 2, 2021, str. 618-636. https://doi.org/10.3390/cimb43020045

Madžarac, Zoran, Lucija Tudor, Marina Šagud, Gordana Nedić Erjavec, Alma Mihaljević Peleš i Nela Pivac. "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia." Current Issues in Molecular Biology 43, br. 2 (2021): 618-636. https://doi.org/10.3390/cimb43020045

Madžarac, Z., et al. (2021) 'The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia', Current Issues in Molecular Biology, 43(2), str. 618-636. doi: 10.3390/cimb43020045

Madžarac Z, Tudor L, Šagud M, Nedić Erjavec G, Mihaljević Peleš A, Pivac N. The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia. Current Issues in Molecular Biology [Internet]. 08.07.2021. [pristupljeno 20.04.2024.];43(2):618-636. doi: 10.3390/cimb43020045

Z. Madžarac, L. Tudor, M. Šagud, G. Nedić Erjavec, A. Mihaljević Peleš i N. Pivac, "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia", Current Issues in Molecular Biology, vol. 43, br. 2, str. 618-636, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:238298. [Citirano: 20.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:238298
Podaci o radu
Naslov (engleski)The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia
AutorZoran Madžarac
AutorLucija Tudor
AutorMarina Šagud
AutorGordana Nedić Erjavec
AutorAlma Mihaljević Peleš
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations were detected in a research sample of 302 patients with schizophrenia. In female patients with schizophrenia, the presence of the G allele or GG genotype of COMT rs4680 and rs4818, as well as GG haplotype rs4818-rs4680, which were all related to higher COMT activity, was associated with an increase in several dimensions of negative symptoms and anhedonia. In male patients with schizophrenia, carriers of the MAO-B rs1799836 A allele, presumably associated with higher MAO-B activity, had a higher severity of alogia, while carriers of the A allele of the MAO-B rs6651806 had a higher severity of negative symptoms. These findings suggest that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Issues in Molecular Biology
Brojčani podacivol. 43, br. 2, str. 618-636
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb43020045
URN:NBNurn:nbn:hr:105:238298
Datum objave publikacije2021-07-08
URL dokumentahttps://www.mdpi.com/1467-3045/43/2/45
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-09 09:10:26