prikaz prve stranice dokumenta Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
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Scientific paper - Original scientific paper
Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
Scientific Reports, 11 (2021), 1; 14020. https://doi.org/10.1038/s41598-021-93054-6
Planinc, Ivo; Garcia-Canadilla, Patricia; Dejea, Hector; Ilic, Ivana; Guasch, Eduard; Zamora, Monica; Crispi, Fàtima; Stampanoni, Marco; Milicic, Davor; Bijnens, Bart; Bonnin, Anne; Čikes, Maja

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Planinc, I., Garcia Canadilla, P., Dejea, H., Ilic, I., Guasch, E., Zamora, M. ... Čikes, M. (2021). Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. Scientific Reports, 11. (1). doi: 10.1038/s41598-021-93054-6

Planinc, Ivo, et al. "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging." Scientific Reports, vol. 11, no. 1, 2021. https://doi.org/10.1038/s41598-021-93054-6

Planinc, Ivo, Patricia Garcia Canadilla, Hector Dejea, Ivana Ilic, Eduard Guasch, Monica Zamora, Fàtima Crispi, et al. "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging." Scientific Reports 11, no. 1 (2021). https://doi.org/10.1038/s41598-021-93054-6

Planinc, I., et al. (2021) 'Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging', Scientific Reports, 11(1). doi: 10.1038/s41598-021-93054-6

Planinc I, Garcia Canadilla P, Dejea H, Ilic I, Guasch E, Zamora M, and sur.. Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. Scientific Reports [Internet]. 2021 July 07 [cited 2024 April 29];11(1). doi: 10.1038/s41598-021-93054-6

I. Planinc, et al., "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging", Scientific Reports, vol. 11, no. 1, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:371839. [Accessed: 29 April 2024]

Metadata
Title (english)Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
AuthorIvo Planinc
AuthorPatricia Garcia-Canadilla
AuthorHector Dejea
AuthorIvana Ilic
AuthorEduard Guasch
AuthorMonica Zamora
AuthorFàtima Crispi
AuthorMarco Stampanoni
AuthorDavor Milicic
AuthorBart Bijnens
AuthorAnne Bonnin
AuthorMaja Čikes
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Abstract Cardiovascular research is in an ongoing quest for a superior imaging method to integrate gross-anatomical information with microanatomy, combined with quantifiable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The objective was to use X-PCI to comprehensively quantify ischemic remodeling of different myocardial structures, from cell to organ level, in a rat model of myocardial infarction. Myocardial infarction-induced remodeling was recreated in a well-established rodent model. Ex vivo rodent hearts were imaged by propagation based X-PCI using two configurations resulting in 5.8 µm and 0.65 µm effective pixel size images. The acquired datasets were used for a comprehensive assessment of macrostructural changes including the whole heart and vascular tree morphology, and quantification of left ventricular myocardial thickness, mass, volume, and organization. On the meso-scale, tissue characteristics were explored and compared with histopathological methods, while microstructural changes were quantified by segmentation of cardiomyocytes and calculation of cross-sectional areas. Propagation based X-PCI provides detailed visualization and quantification of morphological changes on whole organ, tissue, vascular as well as individual cellular level of the ex vivo heart, with a single, non-destructive 3D imaging modality.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 11, no. 1, 14020
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-021-93054-6
URN:NBNurn:nbn:hr:105:371839
Publication2021-07-07
Document URLhttp://www.nature.com/articles/s41598-021-93054-6
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-09 09:26:38