prikaz prve stranice dokumenta Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
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Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
Scientific Reports, 11 (2021), 1; 14020. https://doi.org/10.1038/s41598-021-93054-6
Planinc, Ivo; Garcia-Canadilla, Patricia; Dejea, Hector; Ilic, Ivana; Guasch, Eduard; Zamora, Monica; Crispi, Fàtima; Stampanoni, Marco; Milicic, Davor; Bijnens, Bart; Bonnin, Anne; Čikes, Maja

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Planinc, I., Garcia Canadilla, P., Dejea, H., Ilic, I., Guasch, E., Zamora, M. ... Čikes, M. (2021). Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. Scientific Reports, 11. (1). doi: 10.1038/s41598-021-93054-6

Planinc, Ivo, et al. "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging." Scientific Reports, vol. 11, br. 1, 2021. https://doi.org/10.1038/s41598-021-93054-6

Planinc, Ivo, Patricia Garcia Canadilla, Hector Dejea, Ivana Ilic, Eduard Guasch, Monica Zamora, Fàtima Crispi, et al. "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging." Scientific Reports 11, br. 1 (2021). https://doi.org/10.1038/s41598-021-93054-6

Planinc, I., et al. (2021) 'Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging', Scientific Reports, 11(1). doi: 10.1038/s41598-021-93054-6

Planinc I, Garcia Canadilla P, Dejea H, Ilic I, Guasch E, Zamora M, i sur.. Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. Scientific Reports [Internet]. 07.07.2021. [pristupljeno 22.11.2024.];11(1). doi: 10.1038/s41598-021-93054-6

I. Planinc, et al., "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging", Scientific Reports, vol. 11, br. 1, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:371839. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:371839
Podaci o radu
Naslov (engleski)Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
AutorIvo Planinc
AutorPatricia Garcia-Canadilla
AutorHector Dejea
AutorIvana Ilic
AutorEduard Guasch
AutorMonica Zamora
AutorFàtima Crispi
AutorMarco Stampanoni
AutorDavor Milicic
AutorBart Bijnens
AutorAnne Bonnin
AutorMaja Čikes
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Abstract Cardiovascular research is in an ongoing quest for a superior imaging method to integrate gross-anatomical information with microanatomy, combined with quantifiable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The objective was to use X-PCI to comprehensively quantify ischemic remodeling of different myocardial structures, from cell to organ level, in a rat model of myocardial infarction. Myocardial infarction-induced remodeling was recreated in a well-established rodent model. Ex vivo rodent hearts were imaged by propagation based X-PCI using two configurations resulting in 5.8 µm and 0.65 µm effective pixel size images. The acquired datasets were used for a comprehensive assessment of macrostructural changes including the whole heart and vascular tree morphology, and quantification of left ventricular myocardial thickness, mass, volume, and organization. On the meso-scale, tissue characteristics were explored and compared with histopathological methods, while microstructural changes were quantified by segmentation of cardiomyocytes and calculation of cross-sectional areas. Propagation based X-PCI provides detailed visualization and quantification of morphological changes on whole organ, tissue, vascular as well as individual cellular level of the ex vivo heart, with a single, non-destructive 3D imaging modality.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 11, br. 1, 14020
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-021-93054-6
URN:NBNurn:nbn:hr:105:371839
Datum objave publikacije2021-07-07
URL dokumentahttp://www.nature.com/articles/s41598-021-93054-6
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-09 09:26:38