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Scientific paper - Review paper
Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Journal of Alzheimer's Disease, 82 (2021), 1; 71-105. https://doi.org/10.3233/JAD-210234
Alves, Suélen Santos; Silva-Junior, Rui Milton Patrício da; Servilha-Menezes, Gabriel; Homolak, Jan; Šalković-Petrišić, Melita; Garcia-Cairasco, Norberto

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Alves, S. S., Silva Junior, R. M. P. D., Servilha Menezes, G., Homolak, J., Šalković Petrišić, M. & Garcia Cairasco, N. (2021). Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses. Journal of Alzheimer's Disease, 82. (1), 71-105. doi: 10.3233/JAD-210234

Alves, Suélen Santos, et al. "Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses." Journal of Alzheimer's Disease, vol. 82, no. 1, 2021, pp. 71-105. https://doi.org/10.3233/JAD-210234

Alves, Suélen Santos, Rui Milton Patrício da Silva Junior, Gabriel Servilha Menezes, Jan Homolak, Melita Šalković Petrišić and Norberto Garcia Cairasco. "Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses." Journal of Alzheimer's Disease 82, no. 1 (2021): 71-105. https://doi.org/10.3233/JAD-210234

Alves, S. S., et al. (2021) 'Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses', Journal of Alzheimer's Disease, 82(1), pp. 71-105. doi: 10.3233/JAD-210234

Alves SS, Silva Junior RMPD, Servilha Menezes G, Homolak J, Šalković Petrišić M, Garcia Cairasco N. Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses. Journal of Alzheimer's Disease [Internet]. 2021 [cited 2024 November 09];82(1):71-105. doi: 10.3233/JAD-210234

S. S. Alves, R. M. P. D. Silva Junior, G. Servilha Menezes, J. Homolak, M. Šalković Petrišić and N. Garcia Cairasco, "Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses", Journal of Alzheimer's Disease, vol. 82, no. 1, pp. 71-105, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:761673. [Accessed: 09 November 2024]

Metadata
Title (english)Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
AuthorSuélen Santos Alves
AuthorRui Milton Patrício da Silva-Junior
AuthorGabriel Servilha-Menezes
AuthorJan Homolak
AuthorMelita Šalković-Petrišić
AuthorNorberto Garcia-Cairasco
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Almost 115 years ago, Alois Alzheimer described Alzheimer’s disease (AD) for the first time. Since then, many hypotheses have been proposed. However, AD remains a severe health public problem. The current medical approaches for AD are limited to symptomatic interventions and the complexity of this disease has led to a failure rate of approximately 99.6%in AD clinical trials. In fact, no new drug has been approved for AD treatment since 2003. These failures indicate that we are failing in mimicking this disease in experimental models. Although most studies have focused on the amyloid cascade hypothesis of AD, the literature has made clear that AD is rather a multifactorial disorder. Therefore, the persistence in a single theory has resulted in lost opportunities. In this review, we aim to present the striking points of the long scientific path followed since the description of the first AD case and the main AD hypotheses discussed over the last decades. We also propose insulin resistance as a common link between many other hypotheses.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Alzheimer's Disease
Numberingvol. 82, no. 1, pp. 71-105
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-210234
URN:NBNurn:nbn:hr:105:761673
Publication2021
Document URLhttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-210234
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-06-27 08:09:15