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Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Journal of Alzheimer's Disease, 82 (2021), 1; 71-105. https://doi.org/10.3233/JAD-210234
Alves, Suélen Santos; Silva-Junior, Rui Milton Patrício da; Servilha-Menezes, Gabriel; Homolak, Jan; Šalković-Petrišić, Melita; Garcia-Cairasco, Norberto

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Alves, S. S., Silva Junior, R. M. P. D., Servilha Menezes, G., Homolak, J., Šalković Petrišić, M. i Garcia Cairasco, N. (2021). Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses. Journal of Alzheimer's Disease, 82. (1), 71-105. doi: 10.3233/JAD-210234

Alves, Suélen Santos, et al. "Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses." Journal of Alzheimer's Disease, vol. 82, br. 1, 2021, str. 71-105. https://doi.org/10.3233/JAD-210234

Alves, Suélen Santos, Rui Milton Patrício da Silva Junior, Gabriel Servilha Menezes, Jan Homolak, Melita Šalković Petrišić i Norberto Garcia Cairasco. "Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses." Journal of Alzheimer's Disease 82, br. 1 (2021): 71-105. https://doi.org/10.3233/JAD-210234

Alves, S. S., et al. (2021) 'Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses', Journal of Alzheimer's Disease, 82(1), str. 71-105. doi: 10.3233/JAD-210234

Alves SS, Silva Junior RMPD, Servilha Menezes G, Homolak J, Šalković Petrišić M, Garcia Cairasco N. Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses. Journal of Alzheimer's Disease [Internet]. 2021. [pristupljeno 22.11.2024.];82(1):71-105. doi: 10.3233/JAD-210234

S. S. Alves, R. M. P. D. Silva Junior, G. Servilha Menezes, J. Homolak, M. Šalković Petrišić i N. Garcia Cairasco, "Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses", Journal of Alzheimer's Disease, vol. 82, br. 1, str. 71-105, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:761673. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:761673
Podaci o radu
Naslov (engleski)Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
AutorSuélen Santos Alves
AutorRui Milton Patrício da Silva-Junior
AutorGabriel Servilha-Menezes
AutorJan Homolak
AutorMelita Šalković-Petrišić
AutorNorberto Garcia-Cairasco
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Almost 115 years ago, Alois Alzheimer described Alzheimer’s disease (AD) for the first time. Since then, many hypotheses have been proposed. However, AD remains a severe health public problem. The current medical approaches for AD are limited to symptomatic interventions and the complexity of this disease has led to a failure rate of approximately 99.6%in AD clinical trials. In fact, no new drug has been approved for AD treatment since 2003. These failures indicate that we are failing in mimicking this disease in experimental models. Although most studies have focused on the amyloid cascade hypothesis of AD, the literature has made clear that AD is rather a multifactorial disorder. Therefore, the persistence in a single theory has resulted in lost opportunities. In this review, we aim to present the striking points of the long scientific path followed since the description of the first AD case and the main AD hypotheses discussed over the last decades. We also propose insulin resistance as a common link between many other hypotheses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Alzheimer's Disease
Brojčani podacivol. 82, br. 1, str. 71-105
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-210234
URN:NBNurn:nbn:hr:105:761673
Datum objave publikacije2021
URL dokumentahttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-210234
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-06-27 08:09:15