Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Maihofer, Adam X.; Choi, Karmel W.; Coleman, Jonathan R.I.; Daskalakis, Nikolaos P.; Denckla, Christy A.; Ketema, Elizabeth; Morey, Rajendra A.; Polimanti, Renato; Ratanatharathorn, Andrew; Torres, Katy; Wingo, Aliza P.; Zai, Clement C.; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Soren B.; Andreassen, Ole A.; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegović, Esmina; Borglum, Anders D.; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth A.; Bradley, Bekh; Brashear, Meghan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Chen, Chia-Yen; Dale, Anders M.; Dalvie, Shareefa; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Duncan, Laramie E.; Džubur Kulenović, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gautam, Aarti; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F.; Goçi, Aferdita; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljević, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Karstoft, Karen-Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D.; Logue, Mark W.; Lori, Adriana; Lugonja, Božo; Luykx, Jurjen J.; Lyons, Michael J.; Maples-Keller, Jessica L.; Marmar, Charles; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; Mehta, Divya; Mellor, Rebecca; Michopoulos, Vasiliki; Milberg, William; Miller, Mark W.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O’Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Kenneth J.; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stevens, Jennifer S.; Teicher, Martin H.; Thompson, Wesley K.; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Yehuda, Rachel; Young, Keith A.; Young, Ross McD.; Zhao, Hongyu; Zoellner, Lori A.; Haas, Magali; Lasseter, Heather; Provost, Allison C.; Salem, Rany M.; Sebat, Jonathan; Shaffer, Richard A.; Wu, Tianying; Ripke, Stephan; Daly, Mark J.; Ressler, Kerry J.; Koenen, Karestan C.; Stein, Murray B.; Nievergelt, Caroline M.

doi:10.1016/j.biopsych.2021.09.020

prikaz prve stranice dokumenta Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Scientific paper - Original scientific paper

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Biological Psychiatry, 91 (2022), 7; 626-636. https://doi.org/10.1016/j.biopsych.2021.09.020

Maihofer, Adam X.; Choi, Karmel W.; Coleman, Jonathan R.I.; Daskalakis, Nikolaos P.; Denckla, Christy A.; Ketema, Elizabeth; Morey, Rajendra A.; Polimanti, Renato; Ratanatharathorn, Andrew; Torres, Katy; Wingo, Aliza P.; Zai, Clement C.; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Soren B.; Andreassen, Ole A.; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegović, Esmina; Borglum, Anders D.; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth A.; Bradley, Bekh; Brashear, Meghan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Chen, Chia-Yen; Dale, Anders M.; Dalvie, Shareefa; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Duncan, Laramie E.; Džubur Kulenović, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gautam, Aarti; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F.; Goçi, Aferdita; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljević, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Karstoft, Karen-Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D.; Logue, Mark W.; Lori, Adriana; Lugonja, Božo; Luykx, Jurjen J.; Lyons, Michael J.; Maples-Keller, Jessica L.; Marmar, Charles; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; Mehta, Divya; Mellor, Rebecca; Michopoulos, Vasiliki; Milberg, William; Miller, Mark W.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O’Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Kenneth J.; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stevens, Jennifer S.; Teicher, Martin H.; Thompson, Wesley K.; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Yehuda, Rachel; Young, Keith A.; Young, Ross McD.; Zhao, Hongyu; Zoellner, Lori A.; Haas, Magali; Lasseter, Heather; Provost, Allison C.; Salem, Rany M.; Sebat, Jonathan; Shaffer, Richard A.; Wu, Tianying; Ripke, Stephan; Daly, Mark J.; Ressler, Kerry J.; Koenen, Karestan C.; Stein, Murray B.; Nievergelt, Caroline M. More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

APA 6th Edition

Maihofer, A. X., Choi, K. W., Coleman, J. R., Daskalakis, N. P., Denckla, C. A., Ketema, E. ... Nievergelt, C. M. (2022). Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry, 91. (7), 626-636. doi: 10.1016/j.biopsych.2021.09.020

MLA 8th Edition

Maihofer, Adam X., et al. "Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information." Biological Psychiatry, vol. 91, no. 7, 2022, pp. 626-636. https://doi.org/10.1016/j.biopsych.2021.09.020

Chicago 17th Edition

Maihofer, Adam X., Karmel W. Choi, Jonathan R.I. Coleman, Nikolaos P. Daskalakis, Christy A. Denckla, Elizabeth Ketema, Rajendra A. Morey, et al. "Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information." Biological Psychiatry 91, no. 7 (2022): 626-636. https://doi.org/10.1016/j.biopsych.2021.09.020

Harvard

Maihofer, A. X., et al. (2022) 'Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information', Biological Psychiatry, 91(7), pp. 626-636. doi: 10.1016/j.biopsych.2021.09.020

Vancouver

Maihofer AX, Choi KW, Coleman JR, Daskalakis NP, Denckla CA, Ketema E, and sur.. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry [Internet]. 2022 April [cited 2024 April 25];91(7):626-636. doi: 10.1016/j.biopsych.2021.09.020

IEEE

A. X. Maihofer, et al., "Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information", Biological Psychiatry, vol. 91, no. 7, pp. 626-636, April 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:614686. [Accessed: 25 April 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:614686

Metadata

Title (english)	Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information
Author	Adam X. Maihofer
Author	Karmel W. Choi
Author	Jonathan R.I. Coleman
Author	Nikolaos P. Daskalakis
Author	Christy A. Denckla
Author	Elizabeth Ketema
Author	Rajendra A. Morey
Author	Renato Polimanti
Author	Andrew Ratanatharathorn
Author	Katy Torres
Author	Aliza P. Wingo
Author	Clement C. Zai
Author	Allison E. Aiello
Author	Lynn M. Almli
Author	Ananda B. Amstadter
Author	Soren B. Andersen
Author	Ole A. Andreassen
Author	Paul A. Arbisi
Author	Allison E. Ashley-Koch
Author	S. Bryn Austin
Author	Esmina Avdibegović
Author	Anders D. Borglum
Author	Dragan Babić
Author	Marie Bækvad-Hansen
Author	Dewleen G. Baker
Author	Jean C. Beckham
Author	Laura J. Bierut
Author	Jonathan I. Bisson
Author	Marco P. Boks
Author	Elizabeth A. Bolger
Author	Bekh Bradley
Author	Meghan Brashear
Author	Gerome Breen
Author	Richard A. Bryant
Author	Angela C. Bustamante
Author	Jonas Bybjerg-Grauholm
Author	Joseph R. Calabrese
Author	José M. Caldas-de-Almeida
Author	Chia-Yen Chen
Author	Anders M. Dale
Author	Shareefa Dalvie
Author	Jürgen Deckert
Author	Douglas L. Delahanty
Author	Michelle F. Dennis
Author	Seth G. Disner
Author	Katharina Domschke
Author	Laramie E. Duncan
Author	Alma Džubur Kulenović
Author	Christopher R. Erbes
Author	Alexandra Evans
Author	Lindsay A. Farrer
Author	Norah C. Feeny
Author	Janine D. Flory
Author	David Forbes
Author	Carol E. Franz
Author	Sandro Galea
Author	Melanie E. Garrett
Author	Aarti Gautam
Author	Bizu Gelaye
Author	Joel Gelernter
Author	Elbert Geuze
Author	Charles F. Gillespie
Author	Aferdita Goçi
Author	Scott D. Gordon
Author	Guia Guffanti
Author	Rasha Hammamieh
Author	Michael A. Hauser
Author	Andrew C. Heath
Author	Sian M.J. Hemmings
Author	David Michael Hougaard
Author	Miro Jakovljević
Author	Marti Jett
Author	Eric Otto Johnson
Author	Ian Jones
Author	Tanja Jovanovic
Author	Xue-Jun Qin
Author	Karen-Inge Karstoft
Author	Milissa L. Kaufman
Author	Ronald C. Kessler
Author	Alaptagin Khan
Author	Nathan A. Kimbrel
Author	Anthony P. King
Author	Nastassja Koen
Author	Henry R. Kranzler
Author	William S. Kremen
Author	Bruce R. Lawford
Author	Lauren A.M. Lebois
Author	Catrin Lewis
Author	Israel Liberzon
Author	Sarah D. Linnstaedt
Author	Mark W. Logue
Author	Adriana Lori
Author	Božo Lugonja
Author	Jurjen J. Luykx
Author	Michael J. Lyons
Author	Jessica L. Maples-Keller
Author	Charles Marmar
Author	Nicholas G. Martin
Author	Douglas Maurer
Author	Matig R. Mavissakalian
Author	Alexander McFarlane
Author	Regina E. McGlinchey
Author	Katie A. McLaughlin
Author	Samuel A. McLean
Author	Divya Mehta
Author	Rebecca Mellor
Author	Vasiliki Michopoulos
Author	William Milberg
Author	Mark W. Miller
Author	Charles Phillip Morris
Author	Ole Mors
Author	Preben B. Mortensen
Author	Elliot C. Nelson
Author	Merete Nordentoft
Author	Sonya B. Norman
Author	Meaghan O’Donnell
Author	Holly K. Orcutt
Author	Matthew S. Panizzon
Author	Edward S. Peters
Author	Alan L. Peterson
Author	Matthew Peverill
Author	Robert H. Pietrzak
Author	Melissa A. Polusny
Author	John P. Rice
Author	Victoria B. Risbrough
Author	Andrea L. Roberts
Author	Alex O. Rothbaum
Author	Barbara O. Rothbaum
Author	Peter Roy-Byrne
Author	Kenneth J. Ruggiero
Author	Ariane Rung
Author	Bart P.F. Rutten
Author	Nancy L. Saccone
Author	Sixto E. Sanchez
Author	Dick Schijven
Author	Soraya Seedat
Author	Antonia V. Seligowski
Author	Julia S. Seng
Author	Christina M. Sheerin
Author	Derrick Silove
Author	Alicia K. Smith
Author	Jordan W. Smoller
Author	Scott R. Sponheim
Author	Dan J. Stein
Author	Jennifer S. Stevens
Author	Martin H. Teicher
Author	Wesley K. Thompson
Author	Edward Trapido
Author	Monica Uddin
Author	Robert J. Ursano
Author	Leigh Luella van den Heuvel
Author	Miranda Van Hooff
Author	Eric Vermetten
Author	Christiaan H. Vinkers
Author	Joanne Voisey
Author	Yunpeng Wang
Author	Zhewu Wang
Author	Thomas Werge
Author	Michelle A. Williams
Author	Douglas E. Williamson
Author	Sherry Winternitz
Author	Christiane Wolf
Author	Erika J. Wolf
Author	Rachel Yehuda
Author	Keith A. Young
Author	Ross McD. Young
Author	Hongyu Zhao
Author	Lori A. Zoellner
Author	Magali Haas
Author	Heather Lasseter
Author	Allison C. Provost
Author	Rany M. Salem
Author	Jonathan Sebat
Author	Richard A. Shaffer
Author	Tianying Wu
Author	Stephan Ripke
Author	Mark J. Daly
Author	Kerry J. Ressler
Author	Karestan C. Koenen
Author	Murray B. Stein
Author	Caroline M. Nievergelt
Author's institution	University of Zagreb School of Medicine (Department of Psychiatry and Psychological Medicine)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Psychiatry
Abstract (english)	Background: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). ----- Methods: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. ----- Results: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. ----- Conclusions: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Biological Psychiatry
Numbering	vol. 91, no. 7, pp. 626-636
p-ISSN	0006-3223
DOI	https://doi.org/10.1016/j.biopsych.2021.09.020
URN:NBN	urn:nbn:hr:105:614686
Publication	2022-04
Document URL	https://linkinghub.elsevier.com/retrieve/pii/S0006322321016322
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2022-06-27 09:50:31

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