prikaz prve stranice dokumenta Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information
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Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information
Biological Psychiatry, 91 (2022), 7; 626-636. https://doi.org/10.1016/j.biopsych.2021.09.020
Maihofer, Adam X.; Choi, Karmel W.; Coleman, Jonathan R.I.; Daskalakis, Nikolaos P.; Denckla, Christy A.; Ketema, Elizabeth; Morey, Rajendra A.; Polimanti, Renato; Ratanatharathorn, Andrew; Torres, Katy; Wingo, Aliza P.; Zai, Clement C.; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Soren B.; Andreassen, Ole A.; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegović, Esmina; Borglum, Anders D.; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth A.; Bradley, Bekh; Brashear, Meghan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Chen, Chia-Yen; Dale, Anders M.; Dalvie, Shareefa; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Duncan, Laramie E.; Džubur Kulenović, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gautam, Aarti; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F.; Goçi, Aferdita; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljević, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Karstoft, Karen-Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D.; Logue, Mark W.; Lori, Adriana; Lugonja, Božo; Luykx, Jurjen J.; Lyons, Michael J.; Maples-Keller, Jessica L.; Marmar, Charles; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; Mehta, Divya; Mellor, Rebecca; Michopoulos, Vasiliki; Milberg, William; Miller, Mark W.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O’Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Kenneth J.; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stevens, Jennifer S.; Teicher, Martin H.; Thompson, Wesley K.; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Yehuda, Rachel; Young, Keith A.; Young, Ross McD.; Zhao, Hongyu; Zoellner, Lori A.; Haas, Magali; Lasseter, Heather; Provost, Allison C.; Salem, Rany M.; Sebat, Jonathan; Shaffer, Richard A.; Wu, Tianying; Ripke, Stephan; Daly, Mark J.; Ressler, Kerry J.; Koenen, Karestan C.; Stein, Murray B.; Nievergelt, Caroline M. Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Maihofer, A. X., Choi, K. W., Coleman, J. R., Daskalakis, N. P., Denckla, C. A., Ketema, E. ... Nievergelt, C. M. (2022). Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry, 91. (7), 626-636. doi: 10.1016/j.biopsych.2021.09.020

Maihofer, Adam X., et al. "Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information." Biological Psychiatry, vol. 91, br. 7, 2022, str. 626-636. https://doi.org/10.1016/j.biopsych.2021.09.020

Maihofer, Adam X., Karmel W. Choi, Jonathan R.I. Coleman, Nikolaos P. Daskalakis, Christy A. Denckla, Elizabeth Ketema, Rajendra A. Morey, et al. "Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information." Biological Psychiatry 91, br. 7 (2022): 626-636. https://doi.org/10.1016/j.biopsych.2021.09.020

Maihofer, A. X., et al. (2022) 'Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information', Biological Psychiatry, 91(7), str. 626-636. doi: 10.1016/j.biopsych.2021.09.020

Maihofer AX, Choi KW, Coleman JR, Daskalakis NP, Denckla CA, Ketema E, i sur.. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry [Internet]. 04.2022. [pristupljeno 27.12.2024.];91(7):626-636. doi: 10.1016/j.biopsych.2021.09.020

A. X. Maihofer, et al., "Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information", Biological Psychiatry, vol. 91, br. 7, str. 626-636, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:614686. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:614686
Podaci o radu
Naslov (engleski)Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information
AutorAdam X. Maihofer
AutorKarmel W. Choi
AutorJonathan R.I. Coleman
AutorNikolaos P. Daskalakis
AutorChristy A. Denckla
AutorElizabeth Ketema
AutorRajendra A. Morey
AutorRenato Polimanti
AutorAndrew Ratanatharathorn
AutorKaty Torres
AutorAliza P. Wingo
AutorClement C. Zai
AutorAllison E. Aiello
AutorLynn M. Almli
AutorAnanda B. Amstadter
AutorSoren B. Andersen
AutorOle A. Andreassen
AutorPaul A. Arbisi
AutorAllison E. Ashley-Koch
AutorS. Bryn Austin
AutorEsmina Avdibegović
AutorAnders D. Borglum
AutorDragan Babić
AutorMarie Bækvad-Hansen
AutorDewleen G. Baker
AutorJean C. Beckham
AutorLaura J. Bierut
AutorJonathan I. Bisson
AutorMarco P. Boks
AutorElizabeth A. Bolger
AutorBekh Bradley
AutorMeghan Brashear
AutorGerome Breen
AutorRichard A. Bryant
AutorAngela C. Bustamante
AutorJonas Bybjerg-Grauholm
AutorJoseph R. Calabrese
AutorJosé M. Caldas-de-Almeida
AutorChia-Yen Chen
AutorAnders M. Dale
AutorShareefa Dalvie
AutorJürgen Deckert
AutorDouglas L. Delahanty
AutorMichelle F. Dennis
AutorSeth G. Disner
AutorKatharina Domschke
AutorLaramie E. Duncan
AutorAlma Džubur Kulenović
AutorChristopher R. Erbes
AutorAlexandra Evans
AutorLindsay A. Farrer
AutorNorah C. Feeny
AutorJanine D. Flory
AutorDavid Forbes
AutorCarol E. Franz
AutorSandro Galea
AutorMelanie E. Garrett
AutorAarti Gautam
AutorBizu Gelaye
AutorJoel Gelernter
AutorElbert Geuze
AutorCharles F. Gillespie
AutorAferdita Goçi
AutorScott D. Gordon
AutorGuia Guffanti
AutorRasha Hammamieh
AutorMichael A. Hauser
AutorAndrew C. Heath
AutorSian M.J. Hemmings
AutorDavid Michael Hougaard
AutorMiro Jakovljević
AutorMarti Jett
AutorEric Otto Johnson
AutorIan Jones
AutorTanja Jovanovic
AutorXue-Jun Qin
AutorKaren-Inge Karstoft
AutorMilissa L. Kaufman
AutorRonald C. Kessler
AutorAlaptagin Khan
AutorNathan A. Kimbrel
AutorAnthony P. King
AutorNastassja Koen
AutorHenry R. Kranzler
AutorWilliam S. Kremen
AutorBruce R. Lawford
AutorLauren A.M. Lebois
AutorCatrin Lewis
AutorIsrael Liberzon
AutorSarah D. Linnstaedt
AutorMark W. Logue
AutorAdriana Lori
AutorBožo Lugonja
AutorJurjen J. Luykx
AutorMichael J. Lyons
AutorJessica L. Maples-Keller
AutorCharles Marmar
AutorNicholas G. Martin
AutorDouglas Maurer
AutorMatig R. Mavissakalian
AutorAlexander McFarlane
AutorRegina E. McGlinchey
AutorKatie A. McLaughlin
AutorSamuel A. McLean
AutorDivya Mehta
AutorRebecca Mellor
AutorVasiliki Michopoulos
AutorWilliam Milberg
AutorMark W. Miller
AutorCharles Phillip Morris
AutorOle Mors
AutorPreben B. Mortensen
AutorElliot C. Nelson
AutorMerete Nordentoft
AutorSonya B. Norman
AutorMeaghan O’Donnell
AutorHolly K. Orcutt
AutorMatthew S. Panizzon
AutorEdward S. Peters
AutorAlan L. Peterson
AutorMatthew Peverill
AutorRobert H. Pietrzak
AutorMelissa A. Polusny
AutorJohn P. Rice
AutorVictoria B. Risbrough
AutorAndrea L. Roberts
AutorAlex O. Rothbaum
AutorBarbara O. Rothbaum
AutorPeter Roy-Byrne
AutorKenneth J. Ruggiero
AutorAriane Rung
AutorBart P.F. Rutten
AutorNancy L. Saccone
AutorSixto E. Sanchez
AutorDick Schijven
AutorSoraya Seedat
AutorAntonia V. Seligowski
AutorJulia S. Seng
AutorChristina M. Sheerin
AutorDerrick Silove
AutorAlicia K. Smith
AutorJordan W. Smoller
AutorScott R. Sponheim
AutorDan J. Stein
AutorJennifer S. Stevens
AutorMartin H. Teicher
AutorWesley K. Thompson
AutorEdward Trapido
AutorMonica Uddin
AutorRobert J. Ursano
AutorLeigh Luella van den Heuvel
AutorMiranda Van Hooff
AutorEric Vermetten
AutorChristiaan H. Vinkers
AutorJoanne Voisey
AutorYunpeng Wang
AutorZhewu Wang
AutorThomas Werge
AutorMichelle A. Williams
AutorDouglas E. Williamson
AutorSherry Winternitz
AutorChristiane Wolf
AutorErika J. Wolf
AutorRachel Yehuda
AutorKeith A. Young
AutorRoss McD. Young
AutorHongyu Zhao
AutorLori A. Zoellner
AutorMagali Haas
AutorHeather Lasseter
AutorAllison C. Provost
AutorRany M. Salem
AutorJonathan Sebat
AutorRichard A. Shaffer
AutorTianying Wu
AutorStephan Ripke
AutorMark J. Daly
AutorKerry J. Ressler
AutorKarestan C. Koenen
AutorMurray B. Stein
AutorCaroline M. Nievergelt
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Background: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). ----- Methods: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. ----- Results: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. ----- Conclusions: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiological Psychiatry
Brojčani podacivol. 91, br. 7, str. 626-636
p-ISSN0006-3223
DOIhttps://doi.org/10.1016/j.biopsych.2021.09.020
URN:NBNurn:nbn:hr:105:614686
Datum objave publikacije2022-04
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0006322321016322
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-27 09:50:31