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Scientific paper - Original scientific paper
BMP3 Affects Cortical and Trabecular Long Bone Development in Mice
International Journal of Molecular Sciences, 23 (2022), 2; 785. https://doi.org/10.3390/ijms23020785
Banovac, Ivan; Grgurević, Lovorka; Rumenović, Viktorija; Vukičević, Slobodan; Erjavec, Igor

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Banovac, I., Grgurević, L., Rumenović, V., Vukičević, S. & Erjavec, I. (2022). BMP3 Affects Cortical and Trabecular Long Bone Development in Mice. International Journal of Molecular Sciences, 23. (2). doi: 10.3390/ijms23020785

Banovac, Ivan, et al. "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice." International Journal of Molecular Sciences, vol. 23, no. 2, 2022. https://doi.org/10.3390/ijms23020785

Banovac, Ivan, Lovorka Grgurević, Viktorija Rumenović, Slobodan Vukičević and Igor Erjavec. "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice." International Journal of Molecular Sciences 23, no. 2 (2022). https://doi.org/10.3390/ijms23020785

Banovac, I., et al. (2022) 'BMP3 Affects Cortical and Trabecular Long Bone Development in Mice', International Journal of Molecular Sciences, 23(2). doi: 10.3390/ijms23020785

Banovac I, Grgurević L, Rumenović V, Vukičević S, Erjavec I. BMP3 Affects Cortical and Trabecular Long Bone Development in Mice. International Journal of Molecular Sciences [Internet]. 2022 January 12 [cited 2024 December 27];23(2). doi: 10.3390/ijms23020785

I. Banovac, L. Grgurević, V. Rumenović, S. Vukičević and I. Erjavec, "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice", International Journal of Molecular Sciences, vol. 23, no. 2, January 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:969339. [Accessed: 27 December 2024]

Metadata
Title (english)BMP3 Affects Cortical and Trabecular Long Bone Development in Mice
AuthorIvan Banovac
AuthorLovorka Grgurević
AuthorViktorija Rumenović
AuthorSlobodan Vukičević
AuthorIgor Erjavec
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Bone morphogenetic proteins (BMPs) have a major role in tissue development. BMP3 is synthesized in osteocytes and mature osteoblasts and has an antagonistic effect on other BMPs in bone tissue. The main aim of this study was to fully characterize cortical bone and trabecular bone of long bones in both male and female Bmp3−/− mice. To investigate the effect of Bmp3 from birth to maturity, we compared Bmp3−/− mice with wild-type littermates at the following stages of postnatal development: 1 day (P0), 2 weeks (P14), 8 weeks and 16 weeks of age. Bmp3 deletion was confirmed using X-gal staining in P0 animals. Cartilage and bone tissue were examined in P14 animals using Alcian Blue/Alizarin Red staining. Detailed long bone analysis was performed in 8-week-old and 16-week-old animals using micro-CT. The Bmp3 reporter signal was localized in bone tissue, hair follicles, and lungs. Bone mineralization at 2 weeks of age was increased in long bones of Bmp3−/− mice. Bmp3 deletion was shown to affect the skeleton until adulthood, where increased cortical and trabecular bone parameters were found in young and adult mice of both sexes, while delayed mineralization of the epiphyseal growth plate was found in adult Bmp3−/− mice.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 2, 785
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23020785
URN:NBNurn:nbn:hr:105:969339
Publication2022-01-12
ProjectNumber: KK.01.1.1.01.0008
Title (croatian): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Title (english): Scientific Center of Excellence for Reproductive and Regenerative Medicine
Acronym: CERRM
Leader: Davor JežekScientific Center of Excellence for Reproductive and Regenerative Medicine
Jurisdiction: eu
Document URLhttps://www.mdpi.com/1422-0067/23/2/785
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-07-01 06:34:21