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BMP3 Affects Cortical and Trabecular Long Bone Development in Mice
International Journal of Molecular Sciences, 23 (2022), 2; 785. https://doi.org/10.3390/ijms23020785
Banovac, Ivan; Grgurević, Lovorka; Rumenović, Viktorija; Vukičević, Slobodan; Erjavec, Igor

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Banovac, I., Grgurević, L., Rumenović, V., Vukičević, S. i Erjavec, I. (2022). BMP3 Affects Cortical and Trabecular Long Bone Development in Mice. International Journal of Molecular Sciences, 23. (2). doi: 10.3390/ijms23020785

Banovac, Ivan, et al. "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice." International Journal of Molecular Sciences, vol. 23, br. 2, 2022. https://doi.org/10.3390/ijms23020785

Banovac, Ivan, Lovorka Grgurević, Viktorija Rumenović, Slobodan Vukičević i Igor Erjavec. "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice." International Journal of Molecular Sciences 23, br. 2 (2022). https://doi.org/10.3390/ijms23020785

Banovac, I., et al. (2022) 'BMP3 Affects Cortical and Trabecular Long Bone Development in Mice', International Journal of Molecular Sciences, 23(2). doi: 10.3390/ijms23020785

Banovac I, Grgurević L, Rumenović V, Vukičević S, Erjavec I. BMP3 Affects Cortical and Trabecular Long Bone Development in Mice. International Journal of Molecular Sciences [Internet]. 12.01.2022. [pristupljeno 26.11.2024.];23(2). doi: 10.3390/ijms23020785

I. Banovac, L. Grgurević, V. Rumenović, S. Vukičević i I. Erjavec, "BMP3 Affects Cortical and Trabecular Long Bone Development in Mice", International Journal of Molecular Sciences, vol. 23, br. 2, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:969339. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:969339
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Naslov (engleski)BMP3 Affects Cortical and Trabecular Long Bone Development in Mice
AutorIvan Banovac
AutorLovorka Grgurević
AutorViktorija Rumenović
AutorSlobodan Vukičević
AutorIgor Erjavec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Bone morphogenetic proteins (BMPs) have a major role in tissue development. BMP3 is synthesized in osteocytes and mature osteoblasts and has an antagonistic effect on other BMPs in bone tissue. The main aim of this study was to fully characterize cortical bone and trabecular bone of long bones in both male and female Bmp3−/− mice. To investigate the effect of Bmp3 from birth to maturity, we compared Bmp3−/− mice with wild-type littermates at the following stages of postnatal development: 1 day (P0), 2 weeks (P14), 8 weeks and 16 weeks of age. Bmp3 deletion was confirmed using X-gal staining in P0 animals. Cartilage and bone tissue were examined in P14 animals using Alcian Blue/Alizarin Red staining. Detailed long bone analysis was performed in 8-week-old and 16-week-old animals using micro-CT. The Bmp3 reporter signal was localized in bone tissue, hair follicles, and lungs. Bone mineralization at 2 weeks of age was increased in long bones of Bmp3−/− mice. Bmp3 deletion was shown to affect the skeleton until adulthood, where increased cortical and trabecular bone parameters were found in young and adult mice of both sexes, while delayed mineralization of the epiphyseal growth plate was found in adult Bmp3−/− mice.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 2, 785
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23020785
URN:NBNurn:nbn:hr:105:969339
Datum objave publikacije2022-01-12
ProjektŠifra: KK.01.1.1.01.0008
Naziv (hrvatski): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Naziv (engleski): Scientific Center of Excellence for Reproductive and Regenerative Medicine
Kratica: CERRM
Voditelj: Davor JežekScientific Center of Excellence for Reproductive and Regenerative Medicine
Pravna nadležnost: eu
Financijer: EK
URL dokumentahttps://www.mdpi.com/1422-0067/23/2/785
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-01 06:34:21