prikaz prve stranice dokumenta Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication
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Scientific paper - Case study
Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication
Croatian Medical Journal, 63 (2022), 4; 389-393. https://doi.org/10.3325/cmj.2022.63.389
Zagorec, Nikola; Horvatić, Ivica; Šenjug, Petar; Horaček, Matija; Galešić Ljubanović, Danica; Galešić, Krešimir

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Zagorec, N., Horvatić, I., Šenjug, P., Horaček, M., Galešić Ljubanović, D. & Galešić, K. (2022). Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication. Croatian Medical Journal, 63. (4), 389-393. doi: 10.3325/cmj.2022.63.389

Zagorec, Nikola, et al. "Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication." Croatian Medical Journal, vol. 63, no. 4, 2022, pp. 389-393. https://doi.org/10.3325/cmj.2022.63.389

Zagorec, Nikola, Ivica Horvatić, Petar Šenjug, Matija Horaček, Danica Galešić Ljubanović and Krešimir Galešić. "Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication." Croatian Medical Journal 63, no. 4 (2022): 389-393. https://doi.org/10.3325/cmj.2022.63.389

Zagorec, N., et al. (2022) 'Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication', Croatian Medical Journal, 63(4), pp. 389-393. doi: 10.3325/cmj.2022.63.389

Zagorec N, Horvatić I, Šenjug P, Horaček M, Galešić Ljubanović D, Galešić K. Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication. Croatian Medical Journal [Internet]. 2022 August 31 [cited 2024 November 29];63(4):389-393. doi: 10.3325/cmj.2022.63.389

N. Zagorec, I. Horvatić, P. Šenjug, M. Horaček, D. Galešić Ljubanović and K. Galešić, "Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication", Croatian Medical Journal, vol. 63, no. 4, pp. 389-393, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:149922. [Accessed: 29 November 2024]

Metadata
Title (english)Immune-mediated diseases after coronavirus disease 2019 vaccination: rare but important complication
AuthorNikola Zagorec
AuthorIvica Horvatić
AuthorPetar Šenjug
AuthorMatija Horaček
AuthorDanica Galešić Ljubanović
AuthorKrešimir Galešić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Since the beginning of mass vaccination against coronavirus disease 2019 (COVID-19), vaccine-linked immune-mediated diseases have been increasingly reported. The development of these diseases after COVID-19 vaccination may be attributed to the mechanisms of molecular mimicry and cross-reactivity between the viral spike protein and self-antigens. The most frequent vaccine-linked glomerular disease is immunoglobulin A nephropathy (IgAN). Cutaneous vasculitis has also been reported after COVID-19 vaccination. In both diseases, deposition of immune complexes activates the inflammatory response with end-organ damage. We report on a case of de novo IgAN in a young man and a case of severe cutaneous vasculitis in a 68-year-old woman, both after the second dose of Pfizer-BioNTech COVID-19 vaccine. Neither of the patients had a history of autoimmunity or adverse reactions to vaccines. The temporal association between vaccination and disease development in the absence of other possible intercurrent inciting events suggests a causal mechanism, although coincidental co-occurrence cannot be excluded. In both cases, immunosuppressive treatment was warranted to stop disease progression and to partially or completely resolve the disease. A timely reaction is needed if new-onset signs of an immune-mediated disease appear after vaccination.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 63, no. 4, pp. 389-393
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2022.63.389
URN:NBNurn:nbn:hr:105:149922
Publication2022-08-31
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-09-26 08:23:07