prikaz prve stranice dokumenta Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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Scientific paper - Review paper
Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mediators of Inflammation, 2022 (2022); 8732360. https://doi.org/10.1155/2022/8732360
Kandelouei, Tahmineh; Abbasifard, Mitra; Imani, Danyal; Aslani, Saeed; Razi, Bahman; Fasihi, Mahdieh; Shafiekhani, Sajad; Mohammadi, Keyhan; Jamialahmadi, Tannaz; Reiner, Željko; Sahebkar, Amirhossein

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kandelouei, T., Abbasifard, M., Imani, D., Aslani, S., Razi, B., Fasihi, M. ... Sahebkar, A. (2022). Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mediators of Inflammation, 2022.. doi: 10.1155/2022/8732360

Kandelouei, Tahmineh, et al. "Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Mediators of Inflammation, vol. 2022, 2022. https://doi.org/10.1155/2022/8732360

Kandelouei, Tahmineh, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Mahdieh Fasihi, Sajad Shafiekhani, et al. "Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Mediators of Inflammation 2022 (2022). https://doi.org/10.1155/2022/8732360

Kandelouei, T., et al. (2022) 'Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials', Mediators of Inflammation, 2022. doi: 10.1155/2022/8732360

Kandelouei T, Abbasifard M, Imani D, Aslani S, Razi B, Fasihi M, and sur.. Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mediators of Inflammation [Internet]. 2022 January 28 [cited 2024 December 25];2022. doi: 10.1155/2022/8732360

T. Kandelouei, et al., "Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials", Mediators of Inflammation, vol. 2022, January 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:135365. [Accessed: 25 December 2024]

Metadata
Title (english)Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
AuthorTahmineh Kandelouei
AuthorMitra Abbasifard
AuthorDanyal Imani
AuthorSaeed Aslani
AuthorBahman Razi
AuthorMahdieh Fasihi
AuthorSajad Shafiekhani
AuthorKeyhan Mohammadi
AuthorTannaz Jamialahmadi
AuthorŽeljko Reiner
AuthorAmirhossein Sahebkar
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effect of statins on CRP and hs-CRP levels in patients with cardiovascular diseases (CVDs). ------ Methods: Literature search of the major databases was performed to find eligible RCTs assessing the effect of statins on serum levels of CRP and hs-CRP from the inception until the last week of April 2021. The effect sizes were determined for weighted mean difference (WMD) and 95% confidence intervals (CI). ----- Results: 26 studies were identified (3010 patients and 2968 controls) for hs-CRP and 20 studies (3026 patients and 2968 controls) for CRP. Statins reduced the serum levels of hs-CRP (WMD = -0.97 mg/L; 95% CI: -1.26 to -0.68 mg/L; P < 0.001) and CRP (WMD = -3.05 mg/L; 95% CI: -4.86 to -1.25 mg/L; P < 0.001) in patients with CVDs. Statins decreased the serum levels of hs-CRP in patients receiving both high-intensity and moderate/low-intensity treatments with these drugs. In addition, the duration of treatment longer than 10 weeks decreased hs-CRP levels. Only high-intensity statin treatment could marginally decrease serum levels of CRP in CVDs patients. ----- Conclusions: This meta-analysis showed the efficacy of statins to reduce the concentrations of CRP and hs-CRP in patients with different types of CVDs.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMediators of Inflammation
Numberingvol. 2022, 8732360
p-ISSN0962-9351
e-ISSN1466-1861
DOIhttps://doi.org/10.1155/2022/8732360
URN:NBNurn:nbn:hr:105:135365
Publication2022-01-28
Document URLhttps://www.hindawi.com/journals/mi/2022/8732360/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-26 11:56:25