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Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mediators of Inflammation, 2022 (2022); 8732360. https://doi.org/10.1155/2022/8732360
Kandelouei, Tahmineh; Abbasifard, Mitra; Imani, Danyal; Aslani, Saeed; Razi, Bahman; Fasihi, Mahdieh; Shafiekhani, Sajad; Mohammadi, Keyhan; Jamialahmadi, Tannaz; Reiner, Željko; Sahebkar, Amirhossein

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Kandelouei, T., Abbasifard, M., Imani, D., Aslani, S., Razi, B., Fasihi, M. ... Sahebkar, A. (2022). Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mediators of Inflammation, 2022.. doi: 10.1155/2022/8732360

Kandelouei, Tahmineh, et al. "Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Mediators of Inflammation, vol. 2022, 2022. https://doi.org/10.1155/2022/8732360

Kandelouei, Tahmineh, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Mahdieh Fasihi, Sajad Shafiekhani, et al. "Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Mediators of Inflammation 2022 (2022). https://doi.org/10.1155/2022/8732360

Kandelouei, T., et al. (2022) 'Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials', Mediators of Inflammation, 2022. doi: 10.1155/2022/8732360

Kandelouei T, Abbasifard M, Imani D, Aslani S, Razi B, Fasihi M, i sur.. Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mediators of Inflammation [Internet]. 28.01.2022. [pristupljeno 11.05.2024.];2022. doi: 10.1155/2022/8732360

T. Kandelouei, et al., "Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials", Mediators of Inflammation, vol. 2022, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:135365. [Citirano: 11.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:135365
Podaci o radu
Naslov (engleski)Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
AutorTahmineh Kandelouei
AutorMitra Abbasifard
AutorDanyal Imani
AutorSaeed Aslani
AutorBahman Razi
AutorMahdieh Fasihi
AutorSajad Shafiekhani
AutorKeyhan Mohammadi
AutorTannaz Jamialahmadi
AutorŽeljko Reiner
AutorAmirhossein Sahebkar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effect of statins on CRP and hs-CRP levels in patients with cardiovascular diseases (CVDs). ------ Methods: Literature search of the major databases was performed to find eligible RCTs assessing the effect of statins on serum levels of CRP and hs-CRP from the inception until the last week of April 2021. The effect sizes were determined for weighted mean difference (WMD) and 95% confidence intervals (CI). ----- Results: 26 studies were identified (3010 patients and 2968 controls) for hs-CRP and 20 studies (3026 patients and 2968 controls) for CRP. Statins reduced the serum levels of hs-CRP (WMD = -0.97 mg/L; 95% CI: -1.26 to -0.68 mg/L; P < 0.001) and CRP (WMD = -3.05 mg/L; 95% CI: -4.86 to -1.25 mg/L; P < 0.001) in patients with CVDs. Statins decreased the serum levels of hs-CRP in patients receiving both high-intensity and moderate/low-intensity treatments with these drugs. In addition, the duration of treatment longer than 10 weeks decreased hs-CRP levels. Only high-intensity statin treatment could marginally decrease serum levels of CRP in CVDs patients. ----- Conclusions: This meta-analysis showed the efficacy of statins to reduce the concentrations of CRP and hs-CRP in patients with different types of CVDs.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMediators of Inflammation
Brojčani podacivol. 2022, 8732360
p-ISSN0962-9351
e-ISSN1466-1861
DOIhttps://doi.org/10.1155/2022/8732360
URN:NBNurn:nbn:hr:105:135365
Datum objave publikacije2022-01-28
URL dokumentahttps://www.hindawi.com/journals/mi/2022/8732360/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-26 11:56:25