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Scientific paper - Original scientific paper
Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients
Gut Microbes, 14 (2022), 1; 2083419. https://doi.org/10.1080/19490976.2022.2083419
Čipčić Paljetak, Hana; Barešić, Anja; Panek, Marina; Perić, Mihaela; Matijašić, Mario; Lojkić, Ivana; Barišić, Ana; Vranešić Bender, Darija; Ljubas Kelečić, Dina; Brinar, Marko; Kalauz, Mirjana; Miličević, Marija; Grgić, Dora; Turk, Nikša; Karas, Irena; Čuković-Čavka, Silvija; Krznarić, Željko; Verbanac, Donatella More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Čipčić Paljetak, H., Barešić, A., Panek, M., Perić, M., Matijašić, M., Lojkić, I. ... Verbanac, D. (2022). Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients. Gut Microbes, 14. (1). doi: 10.1080/19490976.2022.2083419

Čipčić Paljetak, Hana, et al. "Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients." Gut Microbes, vol. 14, no. 1, 2022. https://doi.org/10.1080/19490976.2022.2083419

Čipčić Paljetak, Hana, Anja Barešić, Marina Panek, Mihaela Perić, Mario Matijašić, Ivana Lojkić, Ana Barišić, et al. "Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients." Gut Microbes 14, no. 1 (2022). https://doi.org/10.1080/19490976.2022.2083419

Čipčić Paljetak, H., et al. (2022) 'Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients', Gut Microbes, 14(1). doi: 10.1080/19490976.2022.2083419

Čipčić Paljetak H, Barešić A, Panek M, Perić M, Matijašić M, Lojkić I, and sur.. Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients. Gut Microbes [Internet]. 2022 [cited 2024 November 09];14(1). doi: 10.1080/19490976.2022.2083419

H. Čipčić Paljetak, et al., "Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients", Gut Microbes, vol. 14, no. 1, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:317952. [Accessed: 09 November 2024]

Metadata
Title (english)Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients
AuthorHana Čipčić Paljetak
AuthorAnja Barešić
AuthorMarina Panek
AuthorMihaela Perić
AuthorMario Matijašić
AuthorIvana Lojkić
AuthorAna Barišić
AuthorDarija Vranešić Bender
AuthorDina Ljubas Kelečić
AuthorMarko Brinar
AuthorMirjana Kalauz
AuthorMarija Miličević
AuthorDora Grgić
AuthorNikša Turk
AuthorIrena Karas
AuthorSilvija Čuković-Čavka
AuthorŽeljko Krznarić
MBZ: 75865
AuthorDonatella Verbanac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The knowledge on how gut microbes contribute to the inflammatory bowel disease (IBD) at the onset of disease is still scarce. We compared gut microbiota in newly diagnosed, treatment-naïve adult IBD (Crohn's disease (CD) and ulcerative colitis (UC)) to irritable bowel syndrome (IBS) patients and healthy group. Mucosal and fecal microbiota of 49 patients (13 UC, 10 CD, and 26 IBS) before treatment initiation, and fecal microbiota of 12 healthy subjects was characterized by 16S rRNA gene sequencing. Mucosa was sampled at six positions, from terminal ileum to rectum. We demonstrate that mucosal microbiota is spatially homogeneous, cannot be differentiated based on the local inflammation status and yet provides bacterial footprints superior to fecal in discriminating disease phenotypes. IBD groups showed decreased bacterial diversity in mucosa at all taxonomic levels compared to IBS. In CD and UC, Dialister was significantly increased, and expansion of Haemophilus and Propionibacterium characterized UC. Compared to healthy individuals, fecal microbiota of IBD and IBS patients had increased abundance of Proteobacteria, Enterobacteriaceae, in particular. Shift toward reduction of Adlercreutzia and butyrate-producing taxa was found in feces of IBD patients. Microbiota alterations detected in newly diagnosed treatment-naïve adult patients indicate that the microbiota changes are set and detectable at the disease onset and likely have a discerning role in IBD pathophysiology. Our results justify further investigation of the taxa discriminating between disease groups, such as H. parainfluenzae, R. gnavus, Turicibacteriaceae, Dialister, and Adlercreutzia as potential biomarkers of the disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGut Microbes
Numberingvol. 14, no. 1, 2083419
p-ISSN1949-0976
e-ISSN1949-0984
DOIhttps://doi.org/10.1080/19490976.2022.2083419
URN:NBNurn:nbn:hr:105:317952
Publication2022
ProjectNumber: KK.01.1.1.01.0008
Title (english): Reproduktivna i regenerativna medicina - istraživanje novih platformi i potencijala
Leader: Ana Katušić Bojanac
Jurisdiction: Croatia
Document URLhttps://www.tandfonline.com/doi/full/10.1080/19490976.2022.2083419
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-06 10:48:18