prikaz prve stranice dokumenta Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients
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Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients
Gut Microbes, 14 (2022), 1; 2083419. https://doi.org/10.1080/19490976.2022.2083419
Čipčić Paljetak, Hana; Barešić, Anja; Panek, Marina; Perić, Mihaela; Matijašić, Mario; Lojkić, Ivana; Barišić, Ana; Vranešić Bender, Darija; Ljubas Kelečić, Dina; Brinar, Marko; Kalauz, Mirjana; Miličević, Marija; Grgić, Dora; Turk, Nikša; Karas, Irena; Čuković-Čavka, Silvija; Krznarić, Željko; Verbanac, Donatella Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Čipčić Paljetak, H., Barešić, A., Panek, M., Perić, M., Matijašić, M., Lojkić, I. ... Verbanac, D. (2022). Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients. Gut Microbes, 14. (1). doi: 10.1080/19490976.2022.2083419

Čipčić Paljetak, Hana, et al. "Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients." Gut Microbes, vol. 14, br. 1, 2022. https://doi.org/10.1080/19490976.2022.2083419

Čipčić Paljetak, Hana, Anja Barešić, Marina Panek, Mihaela Perić, Mario Matijašić, Ivana Lojkić, Ana Barišić, et al. "Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients." Gut Microbes 14, br. 1 (2022). https://doi.org/10.1080/19490976.2022.2083419

Čipčić Paljetak, H., et al. (2022) 'Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients', Gut Microbes, 14(1). doi: 10.1080/19490976.2022.2083419

Čipčić Paljetak H, Barešić A, Panek M, Perić M, Matijašić M, Lojkić I, i sur.. Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients. Gut Microbes [Internet]. 2022. [pristupljeno 11.05.2024.];14(1). doi: 10.1080/19490976.2022.2083419

H. Čipčić Paljetak, et al., "Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients", Gut Microbes, vol. 14, br. 1, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:317952. [Citirano: 11.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:317952
Podaci o radu
Naslov (engleski)Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients
AutorHana Čipčić Paljetak
AutorAnja Barešić
AutorMarina Panek
AutorMihaela Perić
AutorMario Matijašić
AutorIvana Lojkić
AutorAna Barišić
AutorDarija Vranešić Bender
AutorDina Ljubas Kelečić
AutorMarko Brinar
AutorMirjana Kalauz
AutorMarija Miličević
AutorDora Grgić
AutorNikša Turk
AutorIrena Karas
AutorSilvija Čuković-Čavka
AutorŽeljko Krznarić
MBZ: 75865
AutorDonatella Verbanac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
The knowledge on how gut microbes contribute to the inflammatory bowel disease (IBD) at the onset of disease is still scarce. We compared gut microbiota in newly diagnosed, treatment-naïve adult IBD (Crohn's disease (CD) and ulcerative colitis (UC)) to irritable bowel syndrome (IBS) patients and healthy group. Mucosal and fecal microbiota of 49 patients (13 UC, 10 CD, and 26 IBS) before treatment initiation, and fecal microbiota of 12 healthy subjects was characterized by 16S rRNA gene sequencing. Mucosa was sampled at six positions, from terminal ileum to rectum. We demonstrate that mucosal microbiota is spatially homogeneous, cannot be differentiated based on the local inflammation status and yet provides bacterial footprints superior to fecal in discriminating disease phenotypes. IBD groups showed decreased bacterial diversity in mucosa at all taxonomic levels compared to IBS. In CD and UC, Dialister was significantly increased, and expansion of Haemophilus and Propionibacterium characterized UC. Compared to healthy individuals, fecal microbiota of IBD and IBS patients had increased abundance of Proteobacteria, Enterobacteriaceae, in particular. Shift toward reduction of Adlercreutzia and butyrate-producing taxa was found in feces of IBD patients. Microbiota alterations detected in newly diagnosed treatment-naïve adult patients indicate that the microbiota changes are set and detectable at the disease onset and likely have a discerning role in IBD pathophysiology. Our results justify further investigation of the taxa discriminating between disease groups, such as H. parainfluenzae, R. gnavus, Turicibacteriaceae, Dialister, and Adlercreutzia as potential biomarkers of the disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGut Microbes
Brojčani podacivol. 14, br. 1, 2083419
p-ISSN1949-0976
e-ISSN1949-0984
DOIhttps://doi.org/10.1080/19490976.2022.2083419
URN:NBNurn:nbn:hr:105:317952
Datum objave publikacije2022
ProjektŠifra: KK.01.1.1.01.0008
Naziv (engleski): Reproduktivna i regenerativna medicina - istraživanje novih platformi i potencijala
Voditelj: Ana Katušić Bojanac
Pravna nadležnost: Hrvatska
Financijer: MZO
URL dokumentahttps://www.tandfonline.com/doi/full/10.1080/19490976.2022.2083419
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-06 10:48:18