prikaz prve stranice dokumenta Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review
  Download
PDF 251.79 KB
Scientific paper - Review paper
Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review
Bosnian Journal of Basic Medical Sciences, 22 (2022), 5; 673-682. https://doi.org/10.17305/bjbms.2021.7378
Vranic, Semir; Šerman, Nikola; Glibo, Mislav; Šerman, Ljiljana; Bukvić Mokos, Zrinka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Vranic, S., Šerman, N., Glibo, M., Šerman, Lj. & Bukvić Mokos, Z. (2022). Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. Bosnian Journal of Basic Medical Sciences, 22. (5), 673-682. doi: 10.17305/bjbms.2021.7378

Vranic, Semir, et al. "Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review." Bosnian Journal of Basic Medical Sciences, vol. 22, no. 5, 2022, pp. 673-682. https://doi.org/10.17305/bjbms.2021.7378

Vranic, Semir, Nikola Šerman, Mislav Glibo, Ljiljana Šerman and Zrinka Bukvić Mokos. "Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review." Bosnian Journal of Basic Medical Sciences 22, no. 5 (2022): 673-682. https://doi.org/10.17305/bjbms.2021.7378

Vranic, S., et al. (2022) 'Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review', Bosnian Journal of Basic Medical Sciences, 22(5), pp. 673-682. doi: 10.17305/bjbms.2021.7378

Vranic S, Šerman N, Glibo M, Šerman Lj, Bukvić Mokos Z. Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. Bosnian Journal of Basic Medical Sciences [Internet]. 2022 September 16 [cited 2024 November 22];22(5):673-682. doi: 10.17305/bjbms.2021.7378

S. Vranic, N. Šerman, M. Glibo, Lj. Šerman and Z. Bukvić Mokos, "Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review", Bosnian Journal of Basic Medical Sciences, vol. 22, no. 5, pp. 673-682, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:630488. [Accessed: 22 November 2024]

Metadata
Title (english)Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review
AuthorSemir Vranic
AuthorNikola Šerman
AuthorMislav Glibo
AuthorLjiljana Šerman
AuthorZrinka Bukvić Mokos
MBZ: 279423
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Dermatology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Melanoma is a highly aggressive cancer originating from melanocytes. Its etiopathogenesis is strongly related to genetic, epigenetic, and environmental factors. Melanomas encountered in clinical practice are predominantly sporadic, whereas hereditary melanomas account for approximately 10% of the cases. Hereditary melanomas mainly develop due to mutations in the CDKN2A gene, which encodes two tumor suppressor proteins involved in the cell cycle regulation. CDKN2A, along with CDK4, TERT, and POT1 genes, is a high-risk gene for melanoma. Among the genes that carry a moderate risk are MC1R and MITF, whose protein products are involved in melanin synthesis. The environment also contributes to the development of melanoma. Patients at risk of melanoma should be offered genetic counseling to discuss genetic testing options and the importance of skin UV protection, avoidance of sun exposure, and regular preventive dermatological examinations. Although cancer screening cannot prevent the development of the disease, it allows for early diagnosis when the survival rate is the highest.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 22, no. 5, pp. 673-682
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2021.7378
URN:NBNurn:nbn:hr:105:630488
Publication2022-09-16
Document URLhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/7378
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-09 12:14:26