prikaz prve stranice dokumenta Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review
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Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review
Bosnian Journal of Basic Medical Sciences, 22 (2022), 5; 673-682. https://doi.org/10.17305/bjbms.2021.7378
Vranic, Semir; Šerman, Nikola; Glibo, Mislav; Šerman, Ljiljana; Bukvić Mokos, Zrinka

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Vranic, S., Šerman, N., Glibo, M., Šerman, Lj. i Bukvić Mokos, Z. (2022). Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. Bosnian Journal of Basic Medical Sciences, 22. (5), 673-682. doi: 10.17305/bjbms.2021.7378

Vranic, Semir, et al. "Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review." Bosnian Journal of Basic Medical Sciences, vol. 22, br. 5, 2022, str. 673-682. https://doi.org/10.17305/bjbms.2021.7378

Vranic, Semir, Nikola Šerman, Mislav Glibo, Ljiljana Šerman i Zrinka Bukvić Mokos. "Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review." Bosnian Journal of Basic Medical Sciences 22, br. 5 (2022): 673-682. https://doi.org/10.17305/bjbms.2021.7378

Vranic, S., et al. (2022) 'Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review', Bosnian Journal of Basic Medical Sciences, 22(5), str. 673-682. doi: 10.17305/bjbms.2021.7378

Vranic S, Šerman N, Glibo M, Šerman Lj, Bukvić Mokos Z. Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. Bosnian Journal of Basic Medical Sciences [Internet]. 16.09.2022. [pristupljeno 28.04.2024.];22(5):673-682. doi: 10.17305/bjbms.2021.7378

S. Vranic, N. Šerman, M. Glibo, Lj. Šerman i Z. Bukvić Mokos, "Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review", Bosnian Journal of Basic Medical Sciences, vol. 22, br. 5, str. 673-682, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:630488. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:630488
Podaci o radu
Naslov (engleski)Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review
AutorSemir Vranic
AutorNikola Šerman
AutorMislav Glibo
AutorLjiljana Šerman
AutorZrinka Bukvić Mokos
MBZ: 279423
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA DERMATOVENEROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Melanoma is a highly aggressive cancer originating from melanocytes. Its etiopathogenesis is strongly related to genetic, epigenetic, and environmental factors. Melanomas encountered in clinical practice are predominantly sporadic, whereas hereditary melanomas account for approximately 10% of the cases. Hereditary melanomas mainly develop due to mutations in the CDKN2A gene, which encodes two tumor suppressor proteins involved in the cell cycle regulation. CDKN2A, along with CDK4, TERT, and POT1 genes, is a high-risk gene for melanoma. Among the genes that carry a moderate risk are MC1R and MITF, whose protein products are involved in melanin synthesis. The environment also contributes to the development of melanoma. Patients at risk of melanoma should be offered genetic counseling to discuss genetic testing options and the importance of skin UV protection, avoidance of sun exposure, and regular preventive dermatological examinations. Although cancer screening cannot prevent the development of the disease, it allows for early diagnosis when the survival rate is the highest.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBosnian Journal of Basic Medical Sciences
Brojčani podacivol. 22, br. 5, str. 673-682
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2021.7378
URN:NBNurn:nbn:hr:105:630488
Datum objave publikacije2022-09-16
URL dokumentahttps://www.bjbms.org/ojs/index.php/bjbms/article/view/7378
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-09 12:14:26