prikaz prve stranice dokumenta The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
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Scientific paper - Original scientific paper
The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
European Journal of Clinical Nutrition, 76 (2022), 12; 1675-1681. https://doi.org/10.1038/s41430-022-01189-0
Fehir Šola, Katarina; Vladimir-Knežević, Sanda; Hrabač, Pero; Mucalo, Iva; Saso, Luciano; Verbanac, Donatella

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Fehir Šola, K., Vladimir Knežević, S., Hrabač, P., Mucalo, I., Saso, L. & Verbanac, D. (2022). The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. European Journal of Clinical Nutrition, 76. (12), 1675-1681. doi: 10.1038/s41430-022-01189-0

Fehir Šola, Katarina, et al. "The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial." European Journal of Clinical Nutrition, vol. 76, no. 12, 2022, pp. 1675-1681. https://doi.org/10.1038/s41430-022-01189-0

Fehir Šola, Katarina, Sanda Vladimir Knežević, Pero Hrabač, Iva Mucalo, Luciano Saso and Donatella Verbanac. "The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial." European Journal of Clinical Nutrition 76, no. 12 (2022): 1675-1681. https://doi.org/10.1038/s41430-022-01189-0

Fehir Šola, K., et al. (2022) 'The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial', European Journal of Clinical Nutrition, 76(12), pp. 1675-1681. doi: 10.1038/s41430-022-01189-0

Fehir Šola K, Vladimir Knežević S, Hrabač P, Mucalo I, Saso L, Verbanac D. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. European Journal of Clinical Nutrition [Internet]. 2022 August 04 [cited 2024 November 22];76(12):1675-1681. doi: 10.1038/s41430-022-01189-0

K. Fehir Šola, S. Vladimir Knežević, P. Hrabač, I. Mucalo, L. Saso and D. Verbanac, "The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial", European Journal of Clinical Nutrition, vol. 76, no. 12, pp. 1675-1681, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:628271. [Accessed: 22 November 2024]

Metadata
Title (english)The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
AuthorKatarina Fehir Šola
AuthorSanda Vladimir-Knežević
AuthorPero Hrabač
AuthorIva Mucalo
AuthorLuciano Saso
AuthorDonatella Verbanac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Statistics, Epidemiology and Medical Informatics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Epidemiology
Abstract (english)
Background and objectives: Constipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. ----- Subjects and methods: Sixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture (N = 28) or placebo (N = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time. ----- Results: Supplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group (P < 0.05) when the influence of laxative was excluded. The trend towards an increase in the difference between the two groups, which began 1 week after the probiotic intervention, pointed out to their prolonged effect. There were no significant dependent or independent effects of treatment and time on most of the 27 laboratory blood parameters tested. ----- Conclusions: Multistrain probiotic supplementation was found to be efficacious, safe and well tolerated in the elderly with functional constipation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Clinical Nutrition
Numberingvol. 76, no. 12, pp. 1675-1681
p-ISSN0954-3007
e-ISSN1476-5640
DOIhttps://doi.org/10.1038/s41430-022-01189-0
URN:NBNurn:nbn:hr:105:628271
Publication2022-08-04
Document URLhttps://www.nature.com/articles/s41430-022-01189-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-14 09:50:34